The evolution of RNAi as a defence against viruses and transposable elements
DJ Obbard, KHJ Gordon, AH Buck… - … Transactions of the …, 2009 - royalsocietypublishing.org
RNA interference (RNAi) is an important defence against viruses and transposable elements
(TEs). RNAi not only protects against viruses by degrading viral RNA, but hosts and viruses …
(TEs). RNAi not only protects against viruses by degrading viral RNA, but hosts and viruses …
[HTML][HTML] Exosomes and other extracellular vesicles: the new communicators in parasite infections
G Coakley, RM Maizels, AH Buck - Trends in parasitology, 2015 - cell.com
Extracellular vesicles (EVs) have emerged as a ubiquitous mechanism for transferring
information between cells and organisms across all three kingdoms of life. In addition to their …
information between cells and organisms across all three kingdoms of life. In addition to their …
MicroRNAs: new players in IBD
MicroRNAs (miRNAs) are small non-coding RNAs, 18–23 nucleotides long, which act as
post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the …
post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the …
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the …
C Théry, KW Witwer, E Aikawa… - Journal of …, 2018 - Wiley Online Library
The last decade has seen a sharp increase in the number of scientific publications
describing physiological and pathological functions of extracellular vesicles (EVs), a …
describing physiological and pathological functions of extracellular vesicles (EVs), a …
[HTML][HTML] Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity
AH Buck, G Coakley, F Simbari, HJ McSorley… - Nature …, 2014 - nature.com
In mammalian systems RNA can move between cells via vesicles. Here we demonstrate that
the gastrointestinal nematode Heligmosomoides polygyrus, which infects mice, secretes …
the gastrointestinal nematode Heligmosomoides polygyrus, which infects mice, secretes …
Obstacles and opportunities in the functional analysis of extracellular vesicle RNA–an ISEV position paper
The release of RNA-containing extracellular vesicles (EV) into the extracellular milieu has
been demonstrated in a multitude of different in vitro cell systems and in a variety of body …
been demonstrated in a multitude of different in vitro cell systems and in a variety of body …
[HTML][HTML] The Discovery, Distribution, and Evolution of Viruses Associated with Drosophila melanogaster
CL Webster, FM Waldron, S Robertson, D Crowson… - PLoS …, 2015 - journals.plos.org
Drosophila melanogaster is a valuable invertebrate model for viral infection and antiviral
immunity, and is a focus for studies of insect-virus coevolution. Here we use a metagenomic …
immunity, and is a focus for studies of insect-virus coevolution. Here we use a metagenomic …
[PDF][PDF] Extracellular vesicles from a helminth parasite suppress macrophage activation and constitute an effective vaccine for protective immunity
Recent studies have demonstrated that many parasites release extracellular vesicles (EVs),
yet little is known about the specific interactions of EVs with immune cells or their functions …
yet little is known about the specific interactions of EVs with immune cells or their functions …
Induction of IL-4Rα–dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4–driven murine macrophage proliferation in vivo
D Rückerl, SJ Jenkins, NN Laqtom… - Blood, The Journal …, 2012 - ashpublications.org
Macrophage (MΦ) activation must be tightly controlled to preclude overzealous responses
that cause self-damage. MicroRNAs promote classical MΦ activation by blocking …
that cause self-damage. MicroRNAs promote classical MΦ activation by blocking …
[HTML][HTML] Parasite-derived microRNAs in host serum as novel biomarkers of helminth infection
Background MicroRNAs (miRNAs) are a class of short non-coding RNA that play important
roles in disease processes in animals and are present in a highly stable cell-free form in …
roles in disease processes in animals and are present in a highly stable cell-free form in …