Interactions between the microbiota and the immune system

LV Hooper, DR Littman, AJ Macpherson - science, 2012 - science.org
The large numbers of microorganisms that inhabit mammalian body surfaces have a highly
coevolved relationship with the immune system. Although many of these microbes carry out …

Interactions between commensal intestinal bacteria and the immune system

AJ Macpherson, NL Harris - Nature Reviews Immunology, 2004 - nature.com
Although we might shudder at the thought of billions of bacteria living in our lower intestine,
we are colonized by these passengers shortly after birth. However, the relationship is mostly …

Immune adaptations that maintain homeostasis with the intestinal microbiota

LV Hooper, AJ Macpherson - Nature Reviews Immunology, 2010 - nature.com
Humans harbour nearly 100 trillion intestinal bacteria that are essential for health. Millions of
years of co-evolution have moulded this human–microorganism interaction into a symbiotic …

Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity

JGM Markle, DN Frank, S Mortin-Toth, CE Robertson… - Science, 2013 - science.org
Microbial exposures and sex hormones exert potent effects on autoimmune diseases, many
of which are more prevalent in women. We demonstrate that early-life microbial exposures …

[HTML][HTML] Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota

B Stecher, R Robbiani, AW Walker, AM Westendorf… - PLoS …, 2007 - journals.plos.org
Most mucosal surfaces of the mammalian body are colonized by microbial communities
(“microbiota”). A high density of commensal microbiota inhabits the intestine and shields …

Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria

AJ Macpherson, T Uhr - Science, 2004 - science.org
The enormous number of commensal bacteria in the lower intestine of vertebrates share
abundant molecular patterns used for innate immune recognition of pathogenic bacteria. We …

Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies

KM Kennedy, MC de Goffau, ME Perez-Muńoz… - Nature, 2023 - nature.com
Whether the human fetus and the prenatal intrauterine environment (amniotic fluid and
placenta) are stably colonized by microbial communities in a healthy pregnancy remains a …

A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria

AJ Macpherson, D Gatto, E Sainsbury, GR Harriman… - Science, 2000 - science.org
The immunoglobulin A (IgA) is produced to defend mucosal surfaces from environmental
organisms, but host defenses against the very heavy load of intestinal commensal …

[PDF][PDF] Intestinal bacterial colonization induces mutualistic regulatory T cell responses

MB Geuking, J Cahenzli, MAE Lawson, DCK Ng… - Immunity, 2011 - cell.com
Mammals harbor a dense commensal microbiota in the colon. Regulatory T (Treg) cells are
known to limit microbe-triggered intestinal inflammation and the CD4+ T cell compartment is …

Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses

S Hapfelmeier, MAE Lawson, E Slack, JK Kirundi… - Science, 2010 - science.org
The lower intestine of adult mammals is densely colonized with nonpathogenic (commensal)
microbes. Gut bacteria induce protective immune responses, which ensure host-microbial …