Clinical responses in a phase II study using adoptive transfer of short-term cultured tumor infiltration lymphocytes in metastatic melanoma patients
MJ Besser, R Shapira-Frommer, AJ Treves… - Clinical cancer …, 2010 - AACR
Purpose: Adoptive cell therapy with autologous tumor-infiltrating lymphocytes (TIL) has
shown promising results in metastatic melanoma patients. Although objective response …
shown promising results in metastatic melanoma patients. Although objective response …
Adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma: intent-to-treat analysis and efficacy after failure to prior immunotherapies
MJ Besser, R Shapira-Frommer, O Itzhaki… - Clinical Cancer …, 2013 - AACR
Purpose: Adoptive cell transfer (ACT) using autologous tumor-infiltrating lymphocytes (TIL)
was reported to yield objective responses in about 50% of metastatic patients with …
was reported to yield objective responses in about 50% of metastatic patients with …
Establishment and large-scale expansion of minimally cultured “young” tumor infiltrating lymphocytes for adoptive transfer therapy
O Itzhaki, E Hovav, Y Ziporen, D Levy… - Journal of …, 2011 - journals.lww.com
Abstract Treatment of metastatic melanoma patients with adoptively transferred tumor
infiltrating lymphocytes (TIL) has developed into an effective therapy. Various studies …
infiltrating lymphocytes (TIL) has developed into an effective therapy. Various studies …
Minimally cultured or selected autologous tumor-infiltrating lymphocytes after a lympho-depleting chemotherapy regimen in metastatic melanoma patients
MJ Besser, R Shapira-Frommer, AJ Treves… - Journal of …, 2009 - journals.lww.com
Adoptive cell therapy with autologous tumor-infiltrating lymphocytes (TIL) and high-dose
interleukin-2 (IL-2), after nonmyeloablative chemotherapy, has been shown to result in tumor …
interleukin-2 (IL-2), after nonmyeloablative chemotherapy, has been shown to result in tumor …
Transplantation of human bone marrow mesenchymal stem cells as a thin subretinal layer ameliorates retinal degeneration in a rat model of retinal dystrophy
Vision incapacitation and blindness associated with retinal degeneration affect millions of
people worldwide. Cell based therapy and specifically transplantation of human adult bone …
people worldwide. Cell based therapy and specifically transplantation of human adult bone …
[HTML][HTML] Focus on adoptive T cell transfer trials in melanoma
L Hershkovitz, J Schachter, AJ Treves… - Journal of Immunology …, 2010 - hindawi.com
Adoptive Cell Transfer (ACT) of Tumor-Infiltrating Lymphocytes (TIL) in combination with
lymphodepletion has proven to be an effective treatment for metastatic melanoma patients …
lymphodepletion has proven to be an effective treatment for metastatic melanoma patients …
MDR1 expression identifies human melanoma stem cells
GI Keshet, I Goldstein, O Itzhaki, K Cesarkas… - Biochemical and …, 2008 - Elsevier
ABC transporters are often found to be inherently expressed in a wide variety of stem cells,
where they provide improved protection from toxins. We found a subpopulation of human …
where they provide improved protection from toxins. We found a subpopulation of human …
Cellular copper content modulates differentiation and self‐renewal in cultures of cord blood‐derived CD34+ cells
T Peled, E Landau, E Prus, AJ Treves… - British journal of …, 2002 - Wiley Online Library
Several clinical observations have suggested that copper (Cu) plays a role in regulating
haematopoietic progenitor cell (HPC) development. To further study this role we used an ex …
haematopoietic progenitor cell (HPC) development. To further study this role we used an ex …
[HTML][HTML] Nicotinamide inhibits vasculogenic mimicry, an alternative vascularization pathway observed in highly aggressive melanoma
O Itzhaki, E Greenberg, B Shalmon, A Kubi, AJ Treves… - PloS one, 2013 - journals.plos.org
Vasculogenic mimicry (VM) describes functional vascular channels composed only of tumor
cells and its presence predicts poor prognosis in melanoma patients. Inhibition of this …
cells and its presence predicts poor prognosis in melanoma patients. Inhibition of this …
[HTML][HTML] Epiretinal transplantation of human bone marrow mesenchymal stem cells rescues retinal and vision function in a rat model of retinal degeneration
Vision incapacitation and blindness associated with incurable retinal degeneration affect
millions of people worldwide. In this study, 0.25× 10 6 human bone marrow stem cells (hBM …
millions of people worldwide. In this study, 0.25× 10 6 human bone marrow stem cells (hBM …