[HTML][HTML] Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

J Lloyd-Price, C Arze, AN Ananthakrishnan… - Nature, 2019 - nature.com
Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect
several million individuals worldwide. Crohn's disease and ulcerative colitis are complex …

Guidelines for diagnosis, treatment, and prevention ofclostridium difficileInfections

CM Surawicz, LJ Brandt, DG Binion… - Official journal of the …, 2013 - journals.lww.com
Clostridium difficileinfection (CDI) is a leading cause of hospital-associated gastrointestinal
illness and places a high burden on our health-care system. Patients with CDI typically have …

Epidemiology and risk factors for IBD

AN Ananthakrishnan - Nature reviews Gastroenterology & hepatology, 2015 - nature.com
IBD, comprising Crohn's disease and ulcerative colitis, is a chronic immunologically
mediated disease at the intersection of complex interactions between genetics, environment …

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

L Jostins, S Ripke, RK Weersma, RH Duerr… - Nature, 2012 - nature.com
Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

[PDF][PDF] Intra-and inter-cellular rewiring of the human colon during ulcerative colitis

CS Smillie, M Biton, J Ordovas-Montanes, KM Sullivan… - Cell, 2019 - cell.com
Genome-wide association studies (GWAS) have revealed risk alleles for ulcerative colitis
(UC). To understand their cell type specificities and pathways of action, we generate an atlas …

ACG clinical guideline: ulcerative colitis in adults

DT Rubin, AN Ananthakrishnan… - Official journal of the …, 2019 - journals.lww.com
Ulcerative colitis (UC) is an idiopathic inflammatory disorder. These guidelines indicate the
preferred approach to the management of adults with UC and represent the official practice …

Environmental triggers in IBD: a review of progress and evidence

AN Ananthakrishnan, CN Bernstein… - Nature reviews …, 2018 - nature.com
A number of environmental factors have been associated with the development of IBD.
Alteration of the gut microbiota, or dysbiosis, is closely linked to initiation or progression of …

A prospective study of long-term intake of dietary fiber and risk of Crohn's disease and ulcerative colitis

AN Ananthakrishnan, H Khalili, GG Konijeti… - Gastroenterology, 2013 - Elsevier
Background & Aims Increased intake of dietary fiber has been proposed to reduce the risk of
inflammatory bowel disease (Crohn's disease [CD] and ulcerative colitis [UC]). However, few …

[HTML][HTML] A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients

AB Hall, M Yassour, J Sauk, A Garner, X Jiang… - Genome medicine, 2017 - Springer
Background Inflammatory bowel disease (IBD) is characterized by chronic inflammation of
the gastrointestinal tract that is associated with changes in the gut microbiome. Here, we …

Higher predicted vitamin D status is associated with reduced risk of Crohn's disease

AN Ananthakrishnan, H Khalili, LM Higuchi, Y Bao… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Vitamin D influences innate immunity, which is believed to be
involved in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC). However …