Background & Aims: We have previously shown that aberrant crypt foci (ACF) are the
putative precursor lesions of colorectal adenomas and subsequent cancer in humans using …

A 21-year-old man with diarrhea and edema was admitted to our hospital and diagnosed
with protein-losing enteropathy caused by primary intestinal lymphangiectasia. He was …

Background & Aims: In colorectal adenoma and carcinoma, glutathione S-transferase-π
(GSTP1-1) is highly expressed. K-ras mutation is also known to occur frequently in colorectal …

Cholangiocarcinoma is markedly resistant to chemotherapy and has a dismal prognosis, but
its mechanism of drug resistance is unknown. This study examines whether glutathione S …

Purpose: Long-standing ulcerative colitis (UC) predisposes patients to the development of
colorectal cancer, but surveillance of colitis-associated cancer by detecting the …

Colorectal cancer is a disease with a high mortality rate and it has been increasing in
prevalence worldwide. Chemoprevention, as well as primary and secondary prevention, for …

A39-year-old male was admitted with fever, systemic lymph node swelling, liver dysfunction
and mild splenomegaly. Liver biopsy specimen showedhistiocytic aggregation in portal …

Background & Aims: Aberrant crypt foci, precursors of colonic adenoma, are frequently
positive for glutathione-S-transferase P1-1. Because deoxycholic acid is an apoptosis …

Although hepatic veno-occlusive disease (HVOD) is a common complication of allogenic
bone marrow transplantation (BMT), pulmonary veno-occlusive disease (PVOD) is very rare …

A 61-year-old woman was referred to our hospital for refractory thrombocytopenia (3 x 10
(3)/microliter) and massive melena. Bone marrow aspiration revealed normal cellularity and …