[HTML][HTML] Targeted therapy for hepatocellular carcinoma
A Huang, XR Yang, WY Chung, AR Dennison… - Signal transduction and …, 2020 - nature.com
The last 3 years have seen the emergence of promising targeted therapies for the treatment
of hepatocellular carcinoma (HCC). Sorafenib has been the mainstay of treatment for a …
of hepatocellular carcinoma (HCC). Sorafenib has been the mainstay of treatment for a …
[PDF][PDF] Survival following curative resection for pancreatic ductal adenocarcinoma. A systematic review of the literature
G Garcea, AR Dennison, CJ Pattenden, CP Neal… - Jop, 2008 - researchgate.net
Context Patients with resectable pancreatic cancer comprise a small subgroup of the overall
population with the disease from around 15 to 20%, with nearly all patients dying from their …
population with the disease from around 15 to 20%, with nearly all patients dying from their …
Prognostic molecular markers in hepatocellular carcinoma: a systematic review
CD Mann, CP Neal, G Garcea, MM Manson… - European Journal of …, 2007 - Elsevier
Hepatocellular carcinoma (HCC) is the fifth commonest malignancy worldwide and its
incidence is rising. Surgery, including transplantation, remains the only potentially curative …
incidence is rising. Surgery, including transplantation, remains the only potentially curative …
Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic …
Curcumin, a constituent of the spice turmeric, has been shown to reduce the adenoma
burden in rodent models of colorectal cancer accompanied by a reduction of levels of the …
burden in rodent models of colorectal cancer accompanied by a reduction of levels of the …
[HTML][HTML] Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration
Studies in vitro and in animal models of colorectal and hepatocellular cancers suggest that
curcumin is an effective chemopreventive agent. In this pilot trial, we investigated whether …
curcumin is an effective chemopreventive agent. In this pilot trial, we investigated whether …
[HTML][HTML] Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma
Little is known about the transcriptomic plasticity and adaptive mechanisms of circulating
tumor cells (CTCs) during hematogeneous dissemination. Here we interrogate the …
tumor cells (CTCs) during hematogeneous dissemination. Here we interrogate the …
Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: silibinin levels in plasma, colorectum, and liver and their pharmacodynamic …
Silibinin, a flavonolignan from milk thistle, has intestinal cancer chemopreventive efficacy in
rodents. It is a strong antioxidant and modulates the insulin-like growth factor (IGF) system …
rodents. It is a strong antioxidant and modulates the insulin-like growth factor (IGF) system …
Role of preoperative carbohydrate loading: a systematic review
DK Bilku, AR Dennison, TC Hall… - The Annals of The …, 2014 - publishing.rcseng.ac.uk
INTRODUCTION Surgical stress in the presence of fasting worsens the catabolic state,
causes insulin resistance and may delay recovery. Carbohydrate rich drinks given …
causes insulin resistance and may delay recovery. Carbohydrate rich drinks given …
Cystic lesions of the pancreas: a diagnostic and management dilemma
G Garcea, SL Ong, A Rajesh, CP Neal, CA Pollard… - Pancreatology, 2008 - Elsevier
Abstract Background/Aims: Due to enhanced imaging modalities, pancreatic cysts are being
increasingly detected, often as an incidental finding. They comprise a wide range of differing …
increasingly detected, often as an incidental finding. They comprise a wide range of differing …
Preoperative neutrophil‐to‐lymphocyte ratio (NLR) is associated with reduced disease‐free survival following curative resection of pancreatic adenocarcinoma
G Garcea, N Ladwa, CP Neal… - World journal of …, 2011 - Wiley Online Library
Background Serological proinflammatory markers such as C‐reactive protein (CRP),
neutrophil‐to‐lymphocyte ratio (NLR), and platelet‐to‐lymphocyte ratio (PLR) have been …
neutrophil‐to‐lymphocyte ratio (NLR), and platelet‐to‐lymphocyte ratio (PLR) have been …