[HTML][HTML] PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine

…, F Berlioz, S Guilmeau, A Tsocas… - The Journal of …, 2001 - Am Soc Clin Investig
Dietary proteins are mostly absorbed as di-and tripeptides by the intestinal proton-
dependent transporter PepT1. We have examined the effects of leptin on PepT1 function in …

Duodenal leptin stimulates cholecystokinin secretion: evidence of a positive leptin-cholecystokinin feedback loop

S Guilmeau, M Buyse, A Tsocas, JP Laigneau… - Diabetes, 2003 - Am Diabetes Assoc
Some of the actions of leptin depend on cholecystokinin (CCK). However, it is unknown
whether leptin modulates the release of CCK. Here, we demonstrate in vitro that leptin …

Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice or intestinal …

T Aparicio, L Kotelevets, A Tsocas, JP Laigneau… - Gut, 2005 - gut.bmj.com
Background and aims: Leptin, the product of the ob gene, has been suggested to increase
the risk of colon cancer. However, we have shown that although leptin stimulates epithelial …

Luminal leptin activates mucin-secreting goblet cells in the large bowel

…, R Ducroc, ME Homsi, A Tsocas… - American Journal …, 2006 - journals.physiology.org
Leptin has been suggested to be involved in tissue injury and/or mucosal defence
mechanisms. Here, we studied the effects of leptin on colonic mucus secretion and rat mucin …

PepT1-mediated fMLP transport induces intestinal inflammation in vivo

M Buyse, A Tsocas, F Walker… - American Journal of …, 2002 - journals.physiology.org
In the present study, the effect of H+/peptide transporter (PepT1)-mediated N-
formylmethionyl-leucyl-phenylalanine (fMLP) transport on inflammation in vivo in the rat …

Leptin reduces the development of the initial precancerous lesions induced by azoxymethane in the rat colonic mucosa

T Aparicio, S Guilmeau, H Goiot, A Tsocas… - Gastroenterology, 2004 - Elsevier
Background & Aims: Recent studies suggest that leptin, a hormone involved in food intake
regulation, released into the circulation and gastrointestinal juice, may be a growth factor for …

The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y2 receptor: pharmacological evidence and molecular cloning

…, T Voisin, AM Lorinet, R Ducroc, A Tsocas… - Molecular …, 2001 - ASPET
A peptide YY (PYY)-preferring receptor [PYY> neuropeptide Y (NPY)] was previously
characterized in rat small intestinal crypt cells, where it mediates inhibition of fluid secretion …

Neural modulation of cephalexin intestinal absorption through the di-and tripeptide brush border transporter of rat jejunum in vivo

F Berlioz, S Julien, A Tsocas, J Chariot, C Carbon… - … of Pharmacology and …, 1999 - ASPET
Intestinal absorption of β-lactamine antibiotics (eg, cefixime and cephalexin) has been
shown to proceed through the dipeptide carrier system. In a previous study, nifedipine …

Several receptors mediate the antisecretory effect of peptide YY, neuropeptide Y, and pancreatic polypeptide on VIP-induced fluid secretion in the rat jejunum in vivo

A Souli, J Chariot, T Voisin, O Presset, A Tsocas… - Peptides, 1997 - Elsevier
Souli, A., J. Chariot, T. Voisin, O. Presset, A. Tsocas, A. Balasubramaniam, M. Laburthe and
C. RozÉ. Several receptors mediate the antisecretory effect of peptide YY, neuropeptide Y …

Control of interdigestive and intraduodenal meal-stimulated pancreatic secretion in rats

…, C Nagain, F Hugonet, A Tsocas… - American Journal of …, 1990 - journals.physiology.org
Mechanisms of neural (vagal and cholinergic) and hormonal [cholecystokinin (CCK)] control
of pancreatic exocrine secretion were studied in basal interdigestive conditions and after …