Conclusions The mouse possesses an MUC2 gene, which encodes a mucin that shows very
high homology to the human MUC2. The mouse MUC2 is, just like its human counterpart …

The presence of H. pylori (Hp) in the stomach is associated with chronic gastritis, peptic
ulceration, MALT lymphomas, and chronic atrophic gastritis. To colonize the stomach, Hp …

The current treatment of choice for patients requiring colectomy for ulcerative colitis or
familial adenomatous polyposis is ileoanal anastomosis with pouch creation. Symptomatic …

In children treated with cytostatic drugs, major side effects like malabsorption and
malnutrition are of great concern. Little is known about effects of cytostatics on gene …

Conclusions Single dose MTX treatment leads to increased apoptosis in crypts followed by
an increase in proliferative activity. The MTX-induced decrease in SI expression together …

Pouchitis might develop in up to 46% of patients with an ileoanal pouch. The etiology of
pouchitis is unknown, but it has been associated with decreased levels of short-chain fatty …

Background: Methotrexate (MTX) induced intestinal damage is associated with increased
exposure of the mucosal immune system to vast amounts of microbial stimuli. Because it is …

Conclusions The secretion of 35 S-sulfated MUC2 is increased in active UC. This indicates
an altered sulfation of MUC2 in Ulcerative Colitis. As the synthesis, but not the secretion, of …