Over the last years, hypothalamic inflammation has been linked to the development and
progression of obesity and its sequelae. There is accumulating evidence that this …

The central nervous system (CNS) receives information from afferent neurons, circulating
hormones, and absorbed nutrients and integrates this information to orchestrate the actions …

Wound healing is a coordinated process that initially relies on pro-inflammatory
macrophages, followed by a pro-resolution function of these cells. Changes in cellular …

Obesity and diabetes affect more than half a billion individuals worldwide. Interestingly, the
two conditions do not always coincide and the molecular determinants of" healthy" versus" …

High-fat diet (HFD) feeding induces rapid reprogramming of systemic metabolism. Here, we
demonstrate that HFD feeding of mice downregulates glucose transporter (GLUT)-1 …

Stem cells are highly abundant during early development but become a rare population in
most adult organs. The molecular mechanisms causing stem cells to exit proliferation at a …

Ectopic lipid deposition and altered mitochondrial dynamics contribute to the development of
obesity and insulin resistance. However, the mechanistic link between these processes …

Genetic regulators and environmental stimuli modulate T cell activation in autoimmunity and
cancer. The enzyme co-factor tetrahydrobiopterin (BH4) is involved in the production of …

Skeletal muscle accumulates ceramides in obesity, which contribute to the development of
obesity-associated insulin resistance. However, it remained unclear which distinct ceramide …

Calorie-rich diets induce hyperphagia and promote obesity, although the underlying
mechanisms remain poorly defined. We find that short-term high-fat-diet (HFD) feeding of …