There has been much effort recently to define the role of adipocytokines, which are soluble
mediators derived mainly from adipocytes (fat cells), in the interaction between adipose …

Whereas in most cases a fatty liver remains free of inflammation, 10%‐20% of patients who
have fatty liver develop inflammation and fibrosis (nonalcoholic steatohepatitis [NASH]) …

Insulin resistance (IR) plays a key role in the pathophysiology of obesity-related diseases
such as type 2 diabetes and nonalcoholic fatty liver disease. It has been demonstrated that …

Adipocytokines are mainly adipocyte-derived cytokines regulating metabolism and as such
are key regulators of insulin resistance. Some adipocytokines such as adiponectin and …

The liver constitutes a key organ in systemic metabolism, contributing substantially to the
development of insulin resistance and type 2 diabetes mellitus (T2DM). The mechanisms …

The gut microbiota affects numerous biological functions throughout the body and its
characterisation has become a major research area in biomedicine. Recent studies have …

Experimental evidence from the past years highlights a key role for the intestinal microbiota
in inflammatory and malignant gastrointestinal diseases. Diet exhibits a strong impact on …

Non-alcoholic fatty liver disease (NAFLD), the major cause of abnormal liver function in the
western world, is often associated with obesity and diabetes. In obese individuals, fat …

Objective Alcoholic liver disease (ALD) is a global health problem with limited therapeutic
options. Intestinal barrier integrity and the microbiota modulate susceptibility to ALD …

Background & Aims: Portal fibrosis and linkage is a key feature of progressive disease in
nonalcoholic steatohepatitis (NASH), but not simple steatosis. It is underappreciated and …