This new diagnostic consensus guideline is a joint project of the European Crohn's and
Colitis Organisation [ECCO] and the European Society of Gastrointestinal and Abdominal …

Fistulating Crohn's disease (CD) comprises fistulae arising in the perianal area, together
with those communicating between the intestine and other organs or the abdominal wall …

Inflammatory bowel disease is characterized by a chronic inflammation of the intestinal
mucosa. The mucosal epithelium of the alimentary tract constitutes a key element of the …

When deciding the appropriate treatment strategy for active ulcerative colitis one should
consider the activity, distribution (proctitis, left-sided, extensive 1), and pattern of disease …

Background & Aims Therapies for perianal fistulas in patients with Crohn's disease are often
ineffective in producing long-term healing. We performed a randomized placebo-controlled …

BACKGROUND & AIMS: Vascular endothelial growth factor A (VEGF-A) mediates
angiogenesis and might also have a role in inflammation and immunity. We examined …

Over the past years, mucosal healing has emerged as a major therapeutic goal in clinical
trials in inflammatory bowel diseases. Accumulating evidence indicates that mucosal …

There are several scoring systems presently available to classify disease severity in
ulcerative colitis [UC] within the multiple domains of disease activity, which aid objective …

Background & Aims: Junctional adhesion molecule-A (JAM-A) is localized at the tight
junctions and controls leukocyte migration into the tissues. However, its functional role in …

Mucosal antibody responses play a major role in mediating homeostasis with the intestinal
flora. It has been suggested that imbalance in the IgA+ and IgG+ intestinal B cell repertoire …