Modern methods of monosaccharide synthesis from non-carbohydrate sources
T Hudlicky, DA Entwistle, KK Pitzer, AJ Thorpe - Chemical reviews, 1996 - ACS Publications
Humans have utilized carbohydrates in natural forms such as cellulose in cotton, sucrose in
cane sugar, and sucrose, D-fructose, and D-glucose in honey from the dawn of civilization …
cane sugar, and sucrose, D-fructose, and D-glucose in honey from the dawn of civilization …
The diverse therapeutic actions of pregabalin: is a single mechanism responsible for several pharmacological activities?
SM Stahl, F Porreca, CP Taylor, R Cheung… - Trends in …, 2013 - cell.com
Pregabalin is a specific ligand of the alpha 2-delta (α 2-δ) auxiliary subunit of voltage-gated
calcium channels. A growing body of evidence from studies of anxiety and pain indicate that …
calcium channels. A growing body of evidence from studies of anxiety and pain indicate that …
Structure−Activity Relationships of Pregabalin and Analogues That Target the α2-δ Protein
TR Belliotti, T Capiris, IV Ekhato… - Journal of medicinal …, 2005 - ACS Publications
Pregabalin exhibits robust activity in preclinical assays indicative of potential antiepileptic,
anxiolytic, and antihyperalgesic clinical efficacy. It binds with high affinity to the α2-δ subunit …
anxiolytic, and antihyperalgesic clinical efficacy. It binds with high affinity to the α2-δ subunit …
Herpes zoster infection in patients with ulcerative colitis receiving tofacitinib
KL Winthrop, GY Melmed, S Vermeire… - Inflammatory bowel …, 2018 - academic.oup.com
Background Tofacitinib is an oral, small molecule Janus kinase inhibitor that is being
investigated for ulcerative colitis (UC). Tofacitinib is approved for rheumatoid arthritis and …
investigated for ulcerative colitis (UC). Tofacitinib is approved for rheumatoid arthritis and …
[HTML][HTML] Integrated safety analysis of abrocitinib for the treatment of moderate-to-severe atopic dermatitis from the phase II and phase III clinical trial program
EL Simpson, JI Silverberg, A Nosbaum… - American journal of …, 2021 - Springer
Background Pivotal phase III studies demonstrated that abrocitinib, an oral, once-daily, JAK1-
selective inhibitor, is effective treatment for moderate-to-severe atopic dermatitis (AD) as …
selective inhibitor, is effective treatment for moderate-to-severe atopic dermatitis (AD) as …
[HTML][HTML] Hippocampal CB1 receptors mediate the memory impairing effects of Δ9-tetrahydrocannabinol
LE Wise, AJ Thorpe, AH Lichtman - Neuropsychopharmacology, 2009 - nature.com
It is firmly established that the hippocampus, a brain region implicated in spatial learning,
episodic memory, and consolidation, contains a high concentration of CB 1 receptors …
episodic memory, and consolidation, contains a high concentration of CB 1 receptors …
The disruptive effects of the CB1 receptor antagonist rimonabant on extinction learning in mice are task-specific
F Niyuhire, SA Varvel, AJ Thorpe, RJ Stokes… - …, 2007 - Springer
Rationale Disruption of CB 1 receptor signaling through the use of CB 1 (−/−) mice or the CB
1 receptor antagonist rimonabant (SR141716) has been demonstrated to impair extinction of …
1 receptor antagonist rimonabant (SR141716) has been demonstrated to impair extinction of …
[HTML][HTML] FAAH−/− mice display differential tolerance, dependence, and cannabinoid receptor adaptation after Δ9-tetrahydrocannabinol and anandamide …
KW Falenski, AJ Thorpe, JE Schlosburg… - …, 2010 - nature.com
Repeated administration of Δ 9-tetrahydrocannabinol (THC), the primary psychoactive
constituent of Cannabis sativa, induces profound tolerance that correlates with …
constituent of Cannabis sativa, induces profound tolerance that correlates with …
[PDF][PDF] The α
AJ Thorpe, J Offord - Current Opinion in Investigational Drugs, 2010 - researchgate.net
Currently, there are two drugs on the market, gabapentin (Neurontin) and pregabalin
(Lyrica), that are proposed to exert their therapeutic effect through binding to the α2-δ …
(Lyrica), that are proposed to exert their therapeutic effect through binding to the α2-δ …
Novel Cyclopropyl β-Amino Acid Analogues of Pregabalin and Gabapentin That Target the α2-δ Protein
JB Schwarz, SE Gibbons, SR Graham… - Journal of medicinal …, 2005 - ACS Publications
As part of a program aimed at generating compounds with affinity for the α2-δ subunit of
voltage-gated calcium channels, several novel β-amino acids were prepared using an …
voltage-gated calcium channels, several novel β-amino acids were prepared using an …