[HTML][HTML] Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …
with many important life outcomes. We combine cognitive and genetic data from the …
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci
We have conducted the first meta-analyses for nonsyndromic cleft lip with or without cleft
palate (NSCL/P) using data from the two largest genome-wide association studies published …
palate (NSCL/P) using data from the two largest genome-wide association studies published …
[HTML][HTML] Strengthening regulatory science in academia: STARS, an EU initiative to bridge the translational gap
V Starokozhko, M Kallio, ÅK Howell, AM Salmi… - Drug discovery today, 2021 - Elsevier
Truly disruptive medicine innovation and new treatment paradigms tend to start in non-
commercial research institutions. However, the lack of mutual understanding between …
commercial research institutions. However, the lack of mutual understanding between …
[HTML][HTML] Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis
Background Oesophageal adenocarcinoma represents one of the fastest rising cancers in
high-income countries. Barrett's oesophagus is the premalignant precursor of oesophageal …
high-income countries. Barrett's oesophagus is the premalignant precursor of oesophageal …
Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into …
Objective Gastro-oesophageal reflux disease (GERD) has heterogeneous aetiology
primarily attributable to its symptom-based definitions. GERD genome-wide association …
primarily attributable to its symptom-based definitions. GERD genome-wide association …
Imputation of orofacial clefting data identifies novel risk loci and sheds light on the genetic background of cleft lip±cleft palate and cleft palate only
KU Ludwig, AC Böhmer, J Bowes… - Human molecular …, 2017 - academic.oup.com
Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is among the most common
human birth defects with multifactorial etiology. Here, we present results from a genome …
human birth defects with multifactorial etiology. Here, we present results from a genome …
[PDF][PDF] Sequencing the GRHL3 coding region reveals rare truncating mutations and a common susceptibility variant for nonsyndromic cleft palate
E Mangold, AC Böhmer, N Ishorst, AK Hoebel… - The American Journal of …, 2016 - cell.com
Nonsyndromic cleft lip with/without cleft palate (nsCL/P) and nonsyndromic cleft palate only
(nsCPO) are the most frequent subphenotypes of orofacial clefts. A common syndromic form …
(nsCPO) are the most frequent subphenotypes of orofacial clefts. A common syndromic form …
[HTML][HTML] Meta-analysis reveals genome-wide significance at 15q13 for nonsyndromic clefting of both the lip and the palate, and functional analyses implicate GREM1 …
KU Ludwig, ST Ahmed, AC Böhmer, NB Sangani… - PLoS …, 2016 - journals.plos.org
Nonsyndromic orofacial clefts are common birth defects with multifactorial etiology. The most
common type is cleft lip, which occurs with or without cleft palate (nsCLP and nsCLO …
common type is cleft lip, which occurs with or without cleft palate (nsCLP and nsCLO …
[HTML][HTML] Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases
Gastroesophageal reflux disease (GERD) is caused by gastric acid entering the esophagus.
GERD has high prevalence and is the major risk factor for Barrett's esophagus (BE) and …
GERD has high prevalence and is the major risk factor for Barrett's esophagus (BE) and …
[HTML][HTML] A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization
Previous Mendelian randomization (MR) studies on 25-hydroxyvitamin D (25 (OH) D) and
cancer have typically adopted a handful of variants and found no relationship between 25 …
cancer have typically adopted a handful of variants and found no relationship between 25 …