Traditional functions of DExD/H-box helicases are concerned with RNA metabolism; they
have been shown to play a part in nearly every cellular process that involves RNA. On the …

How somatic mutations accumulate in normal cells is central to understanding cancer
development but is poorly understood. We performed ultradeep sequencing of 74 cancer …

Introduction The human genome is peppered with mobile repetitive elements called long
interspersed nuclear element–1 (L1) retrotransposons. Propagating through RNA and cDNA …

Background Recent evidence suggests a role for the microbiome in pancreatic ductal
adenocarcinoma (PDAC) aetiology and progression. Objective To explore the faecal and …

Somatic cells acquire mutations throughout the course of an individual's life. Mutations
occurring early in embryogenesis are often present in a substantial proportion of, but not all …

The multiple myeloma (MM) genome is heterogeneous and evolves through preclinical and
post-diagnosis phases. Here we report a catalog and hierarchy of driver lesions using …

Fecal microbiota transplantation (FMT) is a therapeutic intervention for inflammatory
diseases of the gastrointestinal tract, but its clinical mode of action and subsequent …

We analyzed whole genomes of unique paired samples from smoldering multiple myeloma
(SMM) patients progressing to multiple myeloma (MM). We report that the genomic …

Genomes are critical units in microbiology, yet ascertaining quality in prokaryotic genome
assemblies remains a formidable challenge. We present GUNC (the Genome UNClutterer) …

INTRODUCTION Gene fusions are often disease-defining events in cancer. The mutational
processes that give rise to fusions, their timing relative to initial diagnosis, and whether they …