Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis
Chronic pancreatitis is a persistent inflammatory disease of the pancreas, in which the
digestive protease trypsin has a fundamental pathogenetic role. Here we have analyzed the …
digestive protease trypsin has a fundamental pathogenetic role. Here we have analyzed the …
Kinetic analysis of the toxicity of pharmaceutical excipients Cremophor EL and RH40 on endothelial and epithelial cells
Cremophor EL and RH40 are widely used excipients in oral and intravenous drug
formulations such as Taxol infusion to improve drug dissolution and absorption. Studies …
formulations such as Taxol infusion to improve drug dissolution and absorption. Studies …
[HTML][HTML] Dodecyl-TPP targets mitochondria and potently eradicates cancer stem cells (CSCs): synergy with FDA-approved drugs and natural compounds (vitamin C …
Elevated mitochondrial biogenesis and/or metabolism are distinguishing features of cancer
cells, as well as Cancer Stem Cells (CSCs), which are involved in tumor initiation, metastatic …
cells, as well as Cancer Stem Cells (CSCs), which are involved in tumor initiation, metastatic …
[HTML][HTML] The Curcumin Analog C-150, Influencing NF-κB, UPR and Akt/Notch Pathways Has Potent Anticancer Activity In Vitro and In Vivo
L Hackler Jr, B Ózsvári, M Gyuris, P Sipos, G Fábián… - PloS one, 2016 - journals.plos.org
C-150 a Mannich-type curcumin derivative, exhibited pronounced cytotoxic effects against
eight glioma cell lines at micromolar concentrations. Inhibition of cell proliferation by C-150 …
eight glioma cell lines at micromolar concentrations. Inhibition of cell proliferation by C-150 …
The effect of sucrose esters on a culture model of the nasal barrier
Sucrose esters are effective solubilizers and there is an interest to use them as
pharmaceutical excipients for nasal drug delivery. We have determined for the first time the …
pharmaceutical excipients for nasal drug delivery. We have determined for the first time the …
Sucrose Esters Increase Drug Penetration, But Do Not Inhibit P‐Glycoprotein in Caco‐2 Intestinal Epithelial Cells
Sucrose fatty acid esters are increasingly used as excipients in pharmaceutical products, but
few data are available on their toxicity profile, mode of action, and efficacy on intestinal …
few data are available on their toxicity profile, mode of action, and efficacy on intestinal …
[HTML][HTML] Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells
Background Cytoplasmic lipid-droplets are common inclusions of eukaryotic cells. Lipid-
droplet binding thalidomide analogs (2, 6-dialkylphenyl-4/5-amino-substituted-5, 6, 7 …
droplet binding thalidomide analogs (2, 6-dialkylphenyl-4/5-amino-substituted-5, 6, 7 …
Compounds blocking methylglyoxal-induced protein modification and brain endothelial injury
Background and Aims Elevated levels of reactive carbonyl species such as methylglyoxal
triggers carbonyl stress and activates a series of inflammatory responses leading to …
triggers carbonyl stress and activates a series of inflammatory responses leading to …
[HTML][HTML] First-in-class candidate therapeutics that target mitochondria and effectively prevent cancer cell metastasis: mitoriboscins and TPP compounds
Cancer stem cells (CSCs) have been proposed to be responsible for tumor recurrence,
distant metastasis and drug-resistance, in the vast majority of cancer patients. Therefore …
distant metastasis and drug-resistance, in the vast majority of cancer patients. Therefore …
A cell-microelectronic sensing technique for the screening of cytoprotective compounds
In recent years, a new cell-based high throughput paradigm has emerged, which seeks to
identify novel, pharmacologically active cytoprotective compounds. The essence of this …
identify novel, pharmacologically active cytoprotective compounds. The essence of this …