Cyclooxygenase 2—implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives
F Halter, AS Tarnawski, A Schmassmann, BM Peskar - Gut, 2001 - gut.bmj.com
Cyclooxygenase (COX), the key enzyme for synthesis of prostaglandins, exists in two
isoforms (COX-1 and COX-2). COX-1 is constitutively expressed in the gastrointestinal tract …
isoforms (COX-1 and COX-2). COX-1 is constitutively expressed in the gastrointestinal tract …
Role of cyclooxygenase isoforms in gastric mucosal defence
BM Peskar - Journal of Physiology-Paris, 2001 - Elsevier
A complex system of interacting mediators exists in the gastric mucosa to strengthen its
resistance against injury. In this system prostaglandins play an important role. Prostaglandin …
resistance against injury. In this system prostaglandins play an important role. Prostaglandin …
Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing
MK Jones, H Wang, BM Peskar, E Levin, RM Itani… - Nature medicine, 1999 - nature.com
Angiogenesis, the formation of new capillary blood vessels, is essential not only for the
growth and metastasis of solid tumors, but also for wound and ulcer healing, because …
growth and metastasis of solid tumors, but also for wound and ulcer healing, because …
Role of prostaglandins in gastroprotection.
BM Peskar, N Maricic - Digestive diseases and sciences, 1998 - europepmc.org
Numerous agents increase gastric mucosal resistance against intraluminal ulcerogens.
Although the precise mechanisms of gastroprotection are uncertain, various endogenous …
Although the precise mechanisms of gastroprotection are uncertain, various endogenous …
Effects of inhibition of prostaglandin endoperoxide synthase‐2 in chronic gastro‐intestinal ulcer models in rats
A Schmassmann, BM Peskar, C Stettler… - British journal of …, 1998 - Wiley Online Library
1 In the stomach, prostaglandins protect the gastric mucosa against injuries. One rate‐
limiting step in prostaglandin synthesis is mediated by prostaglandin endoperoxide …
limiting step in prostaglandin synthesis is mediated by prostaglandin endoperoxide …
Role of ATP-sensitive potassium channels in prostaglandin-mediated gastroprotection in the rat
BM Peskar, K Ehrlich, BA Peskar - Journal of pharmacology and …, 2002 - ASPET
This study compares the involvement of ATP-sensitive potassium (KATP) channels and
prostaglandins in various forms of gastroprotection in the rat. Instillation of 1 ml of 70 …
prostaglandins in various forms of gastroprotection in the rat. Instillation of 1 ml of 70 …
Afferent nerve-mediated protection against deep mucosal damage in the rat stomach
P Holzer, MA Pabst, IT Lippe, BM Peskar, BA Peskar… - Gastroenterology, 1990 - Elsevier
Intragastric capsaicin protects against ethanol-induced gross mucosal lesion formation by
stimulation of afferent nerve endings in the rat stomach. The aims of the present study were …
stimulation of afferent nerve endings in the rat stomach. The aims of the present study were …
Stimulation of prostaglandin biosynthesis mediates gastroprotective effect of rebamipide in rats
A Kleine, S Kluge, BM Peskar - Digestive diseases and sciences, 1993 - Springer
The concept that gastroprotection by agents such as mild irritants, antacids, or sucralfate is
prostaglandin (PG)-mediated has been challenged recently. These agents do not …
prostaglandin (PG)-mediated has been challenged recently. These agents do not …
The effect of parenteral fish oil on leukocyte membrane fatty acid composition and leukotriene-synthesizing capacity in patients with postoperative trauma
BJ Morlion, E Torwesten, H Lessire, G Sturm… - Metabolism, 1996 - Elsevier
The incorporation of ω-3 and ω-6 fatty acids (FAs) into leukocyte membranes and the
leukotriene (LT) B4-, LTB5-, LTC4-, and LTC5-synthesizing capacity in stimulated leukocytes …
leukotriene (LT) B4-, LTB5-, LTC4-, and LTC5-synthesizing capacity in stimulated leukocytes …
Role of calcitonin gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin in the rat
N Lambrecht, M Burchert, M Respondek, KM Müller… - Gastroenterology, 1993 - Elsevier
Background: Capsaicin-sensitive neurons contain various peptides including calcitonin
gene-related peptide. This study examines (1) whether calcitonin generelated peptide is …
gene-related peptide. This study examines (1) whether calcitonin generelated peptide is …