Cyclooxygenase (COX), the key enzyme for synthesis of prostaglandins, exists in two
isoforms (COX-1 and COX-2). COX-1 is constitutively expressed in the gastrointestinal tract …

A complex system of interacting mediators exists in the gastric mucosa to strengthen its
resistance against injury. In this system prostaglandins play an important role. Prostaglandin …

Angiogenesis, the formation of new capillary blood vessels, is essential not only for the
growth and metastasis of solid tumors, but also for wound and ulcer healing, because …

Numerous agents increase gastric mucosal resistance against intraluminal ulcerogens.
Although the precise mechanisms of gastroprotection are uncertain, various endogenous …

1 In the stomach, prostaglandins protect the gastric mucosa against injuries. One rate‐
limiting step in prostaglandin synthesis is mediated by prostaglandin endoperoxide …

This study compares the involvement of ATP-sensitive potassium (KATP) channels and
prostaglandins in various forms of gastroprotection in the rat. Instillation of 1 ml of 70 …

Intragastric capsaicin protects against ethanol-induced gross mucosal lesion formation by
stimulation of afferent nerve endings in the rat stomach. The aims of the present study were …

The concept that gastroprotection by agents such as mild irritants, antacids, or sucralfate is
prostaglandin (PG)-mediated has been challenged recently. These agents do not …

The incorporation of ω-3 and ω-6 fatty acids (FAs) into leukocyte membranes and the
leukotriene (LT) B4-, LTB5-, LTC4-, and LTC5-synthesizing capacity in stimulated leukocytes …

Background: Capsaicin-sensitive neurons contain various peptides including calcitonin
gene-related peptide. This study examines (1) whether calcitonin generelated peptide is …