The postmenopausal hormone therapy (PHT) component of the Women's Health Initiative
(WHI) is composed of two randomized, placebo-controlled, double-blind trials in …

Frailty is an emerging geriatric syndrome that refers to a state of increased vulnerability to
adverse events including mortality, morbidity, disability, hospitalization, and nursing home …

Objectives: To define frailty using simple indicators; to identify risk factors for frailty as targets
for prevention; and to investigate the predictive validity of this frailty classification for death …

Background Calcified plaque in the coronary arteries is a marker for atheromatous-plaque
burden and is predictive of future risk of cardiovascular events. We examined the …

ContextMenopausal hormone therapy has long been credited with many benefits beyond
the indications of relieving hot flashes, night sweats, and vaginal dryness, and it is often …

Most patients with pancreatic ductal adenocarcinoma (PDAC) are diagnosed with advanced
disease and survive less than 12 months. PDAC has been linked with obesity and glucose …

OBJECTIVE: To estimate the effects of estrogen plus progestin (E+ P) therapy on
menopausal symptoms, vaginal bleeding, gynecologic surgery rates, and treatment-related …

Background—Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in
women and may vary by hysterectomy (or oophorectomy) status. This study compared CVD …

Background Older adults with amnestic mild cognitive impairment (aMCI) are at higher risk
for developing Alzheimer disease. Physical performance decline on gait and mobility tasks …

Background Antidepressants are commonly prescribed medications, but their effect on
cardiovascular morbidity and mortality remains unclear. Methods Prospective cohort study of …