User profiles for "author:Barbara Leggett"
Barbara LeggettProfessor, QIMR Berghofer Medical Research Institute Verified email at qimrberghofer.edu.au Cited by 27093 |
Role of the serrated pathway in colorectal cancer pathogenesis
B Leggett, V Whitehall - Gastroenterology, 2010 - Elsevier
The “serrated neoplastic pathway” describes the progression of serrated polyps, including
sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The …
sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The …
Emerging concepts in colorectal neoplasia
An understanding of the mechanisms that explain the initiation and early evolution of
colorectal cancer should facilitate the development of new approaches to effective …
colorectal cancer should facilitate the development of new approaches to effective …
The serrated pathway to colorectal carcinoma: current concepts and challenges
Approximately 30% of colorectal carcinomas develop via a serrated neoplasia pathway,
named for the pattern of crypts in the precursor polyps. Molecular abnormalities consistently …
named for the pattern of crypts in the precursor polyps. Molecular abnormalities consistently …
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
DJ Weisenberger, KD Siegmund, M Campan… - Nature …, 2006 - nature.com
Aberrant DNA methylation of CpG islands has been widely observed in human colorectal
tumors and is associated with gene silencing when it occurs in promoter areas. A subset of …
tumors and is associated with gene silencing when it occurs in promoter areas. A subset of …
[PDF][PDF] Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors
NM Lindor, LJ Burgart, O Leontovich… - Journal of clinical …, 2002 - seom.org
Purpose: To compare microsatellite instability (MSI) testing with immunohistochemical (IHC)
detection of hMLH1 and hMSH2 in colorectal cancer. Patients and Methods: Colorectal …
detection of hMLH1 and hMSH2 in colorectal cancer. Patients and Methods: Colorectal …
Whole-genome landscape of pancreatic neuroendocrine tumours
The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to
more sensitive detection methods, and this increase is creating challenges for clinical …
more sensitive detection methods, and this increase is creating challenges for clinical …
High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy
Background & Aims: Sporadic colorectal cancers with a high degree of microsatellite
instability are a clinically distinct subgroup with a high incidence of BRAF mutation and are …
instability are a clinically distinct subgroup with a high incidence of BRAF mutation and are …
Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis
J Young, LA Simms, KG Biden, C Wynter… - The American journal of …, 2001 - Elsevier
High-level microsatellite instability (MSI-H) is demonstrated in 10 to 15% of sporadic
colorectal cancers and in most cancers presenting in the inherited condition hereditary …
colorectal cancers and in most cancers presenting in the inherited condition hereditary …
Risks of Lynch Syndrome Cancers for MSH6 Mutation Carriers
L Baglietto, NM Lindor, JG Dowty… - Journal of the …, 2010 - academic.oup.com
Background Germline mutations in MSH6 account for 10%–20% of Lynch syndrome
colorectal cancers caused by hereditary DNA mismatch repair gene mutations. Because …
colorectal cancers caused by hereditary DNA mismatch repair gene mutations. Because …
Metachronous colorectal cancer risk for mismatch repair gene mutation carriers: the advantage of more extensive colon surgery
S Parry, AK Win, B Parry, FA Macrae, LC Gurrin… - Gut, 2011 - gut.bmj.com
Background Surgical management of colon cancer for patients with Lynch syndrome who
carry a mismatch repair (MMR) gene mutation is controversial. The decision to remove more …
carry a mismatch repair (MMR) gene mutation is controversial. The decision to remove more …