The “serrated neoplastic pathway” describes the progression of serrated polyps, including
sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The …

An understanding of the mechanisms that explain the initiation and early evolution of
colorectal cancer should facilitate the development of new approaches to effective …

Approximately 30% of colorectal carcinomas develop via a serrated neoplasia pathway,
named for the pattern of crypts in the precursor polyps. Molecular abnormalities consistently …

Aberrant DNA methylation of CpG islands has been widely observed in human colorectal
tumors and is associated with gene silencing when it occurs in promoter areas. A subset of …

Purpose: To compare microsatellite instability (MSI) testing with immunohistochemical (IHC)
detection of hMLH1 and hMSH2 in colorectal cancer. Patients and Methods: Colorectal …

The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to
more sensitive detection methods, and this increase is creating challenges for clinical …

Background & Aims: Sporadic colorectal cancers with a high degree of microsatellite
instability are a clinically distinct subgroup with a high incidence of BRAF mutation and are …

High-level microsatellite instability (MSI-H) is demonstrated in 10 to 15% of sporadic
colorectal cancers and in most cancers presenting in the inherited condition hereditary …

Background Germline mutations in MSH6 account for 10%–20% of Lynch syndrome
colorectal cancers caused by hereditary DNA mismatch repair gene mutations. Because …

Background Surgical management of colon cancer for patients with Lynch syndrome who
carry a mismatch repair (MMR) gene mutation is controversial. The decision to remove more …