Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …

Type 1 diabetes mellitus results from a T-cell mediated autoimmune destruction of the
pancreatic beta cells in genetically predisposed individuals. The knowledge of the …

Type 1 diabetes is characterized by recognition of one or more β-cell proteins by the
immune system. The list of target antigens in this disease is ever increasing and it is …

Type 1 diabetes is a T-cell–mediated disease that is associated with loss of immunological
tolerance to self-antigens. The mechanisms involved in maintenance of peripheral tolerance …

A direct association of islet-autoreactive T cells with β cell destruction in human pancreatic
islets from type 1 diabetes (T1D) patients has never been demonstrated, and little is known …

Type 1 diabetes is characterized by T cell-mediated autoimmune destruction of pancreatic β
cells. Several studies have suggested an association between Coxsackie enterovirus …

According to the quality of response they mediate, autoreactive T cells recognizing islet β
cell peptides could represent both disease effectors in the development of type 1 diabetes …

Specific therapy with modulated DC may restore immunological tolerance, thereby obviating
the need for chronic immunosuppression in transplantation or autoimmunity. In this study we …

The final pathway of β cell destruction leading to insulin deficiency, hyperglycemia, and
clinical type 1 diabetes is unknown. Here we show that circulating CTLs can kill β cells via …

Type 1 diabetes is a T cell-mediated autoimmune disease, and insulin is an important target
of the autoimmune response associated with β cell destruction. The mechanism of …