[HTML][HTML] Mend your fences: the epithelial barrier and its relationship with mucosal immunity in inflammatory bowel disease

E Martini, SM Krug, B Siegmund, MF Neurath… - Cellular and molecular …, 2017 - Elsevier
The intestinal epithelium can be easily disrupted during gut inflammation as seen in
inflammatory bowel disease (IBD), such as ulcerative colitis or Crohn's disease. For a long …

[HTML][HTML] Diversity of intestinal macrophages in inflammatory bowel diseases

AA Kühl, U Erben, LI Kredel, B Siegmund - Frontiers in immunology, 2015 - frontiersin.org
Macrophages as innate immune cells and fast responders to antigens play a central role in
protecting the body from the luminal content at a huge interface. Chronic inflammation in …

Location is important: differentiation between ileal and colonic Crohn's disease

R Atreya, B Siegmund - Nature Reviews Gastroenterology & …, 2021 - nature.com
Crohn's disease can affect any part of the gastrointestinal tract; however, current European
and national guidelines worldwide do not differentiate between small-intestinal and colonic …

[HTML][HTML] Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

J Meinhardt, J Radke, C Dittmayer, J Franz… - Nature …, 2021 - nature.com
The newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
causes COVID-19, a pandemic respiratory disease. Moreover, thromboembolic events …

[HTML][HTML] A guide to histomorphological evaluation of intestinal inflammation in mouse models

U Erben, C Loddenkemper, K Doerfel… - … journal of clinical and …, 2014 - ncbi.nlm.nih.gov
Histomorphology remains a powerful routine evaluating intestinal inflammation in animal
models. Emphasizing the focus of a given animal study, histopathology can overstate …

[HTML][HTML] Impaired IL-18 processing protects caspase-1–deficient mice from ischemic acute renal failure

VY Melnikov, T Ecder, G Fantuzzi… - The Journal of …, 2001 - Am Soc Clin Investig
We sought to determine whether mice deficient in the proinflammatory caspase-1, which
cleaves precursors of IL-1β and IL-18, were protected against ischemic acute renal failure …

A guiding map for inflammation

MG Netea, F Balkwill, M Chonchol, F Cominelli… - Nature …, 2017 - nature.com
Biologists, physicians and immunologists have contributed to the understanding of the
cellular participants and biological pathways involved in inflammation. Here, we provide a …

The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines

F Leoni, A Zaliani, G Bertolini, G Porro… - Proceedings of the …, 2002 - National Acad Sciences
Suberoylanilide hydroxamic acid (SAHA) is a hydroxamic acid-containing hybrid polar
molecule; SAHA specifically binds to and inhibits the activity of histone deacetylase …

IL-1β-converting enzyme (caspase-1) in intestinal inflammation

B Siegmund, HA Lehr, G Fantuzzi… - Proceedings of the …, 2001 - National Acad Sciences
IL-1β-converting enzyme (ICE; caspase-1) is the intracellular protease that cleaves the
precursors of IL-1β and IL-18 into active cytokines. In the present study, the effect of ICE …

[HTML][HTML] Neutrophil-independent mechanisms of caspase-1–and IL-18–mediated ischemic acute tubular necrosis in mice

VY Melnikov, S Faubel, B Siegmund… - The Journal of …, 2002 - Am Soc Clin Investig
Having recently described the injurious role of caspase-1–mediated production of the
proinflammatory cytokine IL-18 in ischemic acute renal failure (ARF), we report here on the …