Cancer is a complex disease that is dictated by both cancer cell-intrinsic and cell-extrinsic
processes. Adenosine is an ancient extracellular signalling molecule that can regulate …

Background The introduction of proton pump inhibitors (PPIs) into clinical practice has
revolutionized the management of acid-related diseases. Studies in primary care and …

Neurological diseases, such as Parkinson's disease, Alzheimer's disease, amyotrophic
lateral sclerosis (ALS) and multiple sclerosis, are often associated with functional …

Background There are several guidelines addressing the issues around the use of NSAIDs.
However, none has specifically addressed the upper versus lower gastrointestinal (GI) risk …

Several lines of evidence point out the relevance of nucleotide-binding oligomerization
domain leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome …

Over recent years, significant advances in cancer immunotherapy have been made due to a
better understanding of the principles underlying tumor biology and immunology. In this …

Hydrogen sulphide (H2S) is emerging as an important endogenous modulator, which
exhibits the beneficial effects of nitric oxide (NO) on the cardiovascular (CV) system, without …

Background Irritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal
tract characterized by abdominal discomfort, pain and changes in bowel habits, often …

The adenosine pathway is a powerful evolutionarily selected mechanism aimed at a fine
modulation of inflammatory responses and protection of tissues from injuries. Adenosine …

Growing evidence highlights the relevance of microbiota-gut-brain axis in the maintenance
of brain homeostasis as well as in the pathophysiology of major neurological and psychiatric …