Secondary ion mass spectrometry (SIMS) microscopy, a mass spectrometry method
designed in the 1960s, offers new analytical capabilities, high sensitivity (ppm to ppb …

We attempted to indicate the requirements for biomedical applications of SIMS microscopy.
Sample preparation methodology should preserve both the structural and the chemical …

Specific markers for pancreatic or biliary cancer have been developed in the past few years.
Ca 19-9 has a good sensitivity but it is also increased in benign cholestasis. Mutations in the …

The purpose of this review is to present the recent developments in the medical applications
of SIMS microscopy. This technique is one of the microanalytical mass spectrometry …

Background & Aims: The molecular mechanism of hereditary persistence of α-fetoprotein
(HPAFP) has been previously described in a large Scottish family, consisting of a− 119G> A …

Background Iodinated and gadolinium-based contrast media (ICM; GBCM) induce
immediate hypersensitivity (IH) reactions. Differentiating allergic from non-allergic IH is …

Objective: To evaluate the value of biliary carcino-embryonic antigen (CEA) in the differential
diagnosis of malignant and benign hepatopancreatobiliary disease. Patients: One hundred …

Microdosimetric evaluations of targeted radiotherapy of neuroblastoma with
metaiodobenzylguanidine (MIBG) require precise assessment of the intracellular and …

This paper examines the clinical expression of asthma in a group of patients displaying
rhinitis according to age, sex, associated symptoms, smoking, familial history of asthma …

Elemental Imaging. Direct electronegative ion imaging was performed with a low current 10
keV Cs4@ primary beam (20— 30 nA) focusedon areas of 60 and 150@ in diameter. A …