Hepatic uptake and biliary excretion of organic anions (eg, bile acids and bilirubin) is
mediated by hepatobiliary transport systems. Defects in transporter expression and function …

MDR1 (ABCB1), MRP2 (ABCC2), and BCRP (ABCG2) are members of the family of ATP
binding cassette (ABC) transporters. These are plasma membrane transporters that are …

Nonalcoholic fatty liver disease (NAFLD) is becoming a frequent liver disease, especially in
patients with metabolic syndrome and especially in Western countries. Complications of …

Hepatobiliary transporters are down–regulated in toxic and cholestatic liver injury. Cytokines
such as tumor necrosis factor α (TNF–α) and interleukin 1β (IL–1β) are attributed to mediate …

MRP2 is a canalicular transporter in hepatocytes mediating the transport of a wide spectrum
of amphipathic compounds. This includes organic anions but also compounds complexed …

AIM: To investigate the effect of Lactobacillus-containing commercially available probiotic
formulations in Germany during antibiotic treatment with an analysis of cost-efficiency …

Cholestasis develops during inflammatory conditions characterized by the release of
cytokines like interleukin-6 (IL-6), which is the major player in the hepatic acute-phase …

Proinflammatory cytokines such as TNF-α and IL-1β lead to downregulation of hepatic
organic anion transporters in cholestasis. This adapted response is transcriptionally …

Background/Aims: Hepatobiliary transporters are down-regulated in cholestasis, but their
expression in acute, non-cholestatic, cytokine-mediated liver injury is unknown. Thus we …

Background/Aims: Estrogen-mediated cholestasis is an important clinical entity, but its
molecular pathophysiology is still not fully understood. Impaired sodium-dependent uptake …