A large body of information about antigen receptors on the surface of T lymphocytes has
been gathered in the last five years (1, 2). T cell receptors use a variable region gene pool …

Several viral vector-based gene therapy drugs have now received marketing approval. A
much larger number of additional viral vectors are in various stages of clinical trials for the …

T cells contribute to the initiation and perpetuation of autoimmunity in systemic lupus
erythematosus (SLE), and seem to be directly involved in the development of related organ …

In addition to triggering the activation of B-or T-cell antigen receptors, the binding of a ligand
to its receptor at the cell surface can sometimes determine the physiological outcome of …

To improve our ability to identify hematopoietic stem cells (HSCs) and their localization in
vivo, we compared the gene expression profiles of highly purified HSCs and non-self …

The presence of natural killer (NK) cells contributes to early defense against murine
cytomegalovirus (MCMV) infection. Although NK cells can mediate in vivo protection against …

Abstract HUMAN cluster-of-differentiation 1 (CD1) is a family of cell surface glycoproteins of
unknown function expressed on immature thymocytes, epidermal Langerhans cells and a …

Commitment to the T and natural killer T (NKT) cell lineages is determined during αβ T cell
receptor (TCR)-mediated interactions of common precursors with ligand-expressing cells in …

The cytokine macrophage-migration inhibitory factor (MIF) is secreted by a number of cell
types upon induction by lipopolysaccharide (LPS). Because colitis is dependent on interplay …

The role of the T3/antigen receptor complex is summarized by the diagram presented in
Figure 4. Signals transmitted through T3/Ti activate a phosphodiesterase. This enzyme acts …