The incidence of hepatocellular carcinoma (HCC) has been rising worldwide over the last
20 years and is expected to increase until 2030 in some countries including the United …

Background The liver plays a central role in coagulation and fibrinolysis but is also closely
intertwined with the function and number of blood platelets. Aim To describe and integrate …

Hepatocellular carcinoma (HCC) is a major health problem worldwide responsible for 500
000 deaths annually. A number of risk factors are associated with either the induction of the …

Background The epidermal growth factor receptor (EGFR), which participates in signaling
pathways that are deregulated in cancer cells, commonly appears on colorectal-cancer …

Background Immune checkpoint blockade therapy has shown promising results in patients
with advanced hepatocellular carcinoma. We aimed to assess the efficacy and safety of …

Background Biliary tract cancers, which arise from the intrahepatic or extrahepatic bile ducts
and the gallbladder, generally have a poor prognosis and are rising in incidence worldwide …

Purpose To determine whether addition of the farnesyltransferase inhibitor tipifarnib
(Zarnestra, R115777; Johnson and Johnson Pharmaceutical Research and Development …

Sorafenib: sorafenib has only been evaluated in the firstline setting. Phase IV/observational
studies have not revealed new safety signals in patients with Childe Pugh B cirrhosis 4 [I, A; …

Purpose Treatment with gemcitabine provides modest benefits in patients with metastatic
pancreatic cancer. The addition of erlotinib to gemcitabine shows a small but significant …

Most tumours have an aberrantly activated lipid metabolism, that enables them to
synthesize, elongate and desaturate fatty acids to support proliferation. However, only …