A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp …

FF Anhê, D Roy, G Pilon, S Dudonné, S Matamoros… - Gut, 2015 - gut.bmj.com
Objective The increasing prevalence of obesity and type 2 diabetes (T2D) demonstrates the
failure of conventional treatments to curb these diseases. The gut microbiota has been put …

[HTML][HTML] Apple peel polyphenols and their beneficial actions on oxidative stress and inflammation

MC Denis, A Furtos, S Dudonne, A Montoudis… - PLoS …, 2013 - journals.plos.org
Since gastrointestinal mucosa is constantly exposed to reactive oxygen species from various
sources, the presence of antioxidants may contribute to the body's natural defenses against …

PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells

E Levy, ABD Ouadda, S Spahis, AT Sane, C Garofalo… - Atherosclerosis, 2013 - Elsevier
OBJECTIVES: The proprotein convertase subtillisin/kexin type 9 (PCSK9) regulates
cholesterol metabolism via degradation of low-density lipoprotein receptor (LDLr). Although …

Prevention of oxidative stress, inflammation and mitochondrial dysfunction in the intestine by different cranberry phenolic fractions

MC Denis, Y Desjardins, A Furtos, V Marcil… - Clinical …, 2015 - portlandpress.com
Cranberry fruit has been reported to have high antioxidant effectiveness that is potentially
linked to its richness in diversified polyphenolic content. The aim of the present study was to …

[HTML][HTML] Research communication: butyrate impairs lipid transport by inhibiting microsomal triglyceride transfer protein in Caco-2 cells

V Marcil, C Garofalo, E Levy, E Delvin - The Journal of nutrition, 2003 - Elsevier
Recently, the idea was advanced that short-chain fatty acids (SCFA) may potentially regulate
intestinal fat absorption. The aim of this investigation was to examine the effects of butyrate …

Modulation of lipid synthesis, apolipoprotein biogenesis, and lipoprotein assembly by butyrate

V Marcil, E Delvin, E Seidman… - American Journal …, 2002 - journals.physiology.org
Short-chain fatty acids (SCFAs) are potent modulators of the growth, function, and
differentiation of intestinal epithelia. In addition, high-fiber diets may protect against the …

Maternal and fetal leptin, adiponectin levels and associations with fetal insulin sensitivity

ZC Luo, AM Nuyt, E Delvin, WD Fraser, P Julien… - …, 2013 - Wiley Online Library
Objective: It remains uncertain whether leptin and adiponectin levels are correlated in
maternal vs. fetal circulations. Little is known about whether leptin and adiponectin affect …

[HTML][HTML] Lipid and lipoprotein abnormalities in acute lymphoblastic leukemia survivors [S]

S Morel, J Leahy, M Fournier, B Lamarche… - Journal of lipid …, 2017 - ASBMB
Survivors of acute lymphoblastic leukemia (ALL), the most common cancer in children, are at
increased risk of developing late cardiometabolic conditions. However, the mechanisms are …

Apple peel polyphenols reduce mitochondrial dysfunction in mice with DSS-induced ulcerative colitis

PR Yeganeh, J Leahy, S Spahis, N Patey… - The Journal of nutritional …, 2018 - Elsevier
Inflammatory bowel diseases (IBDs) are multifaceted and relapsing immune disorders,
which necessitate long-term dependence on powerful drugs. As the use of natural product …

Apple peel polyphenols: a key player in the prevention and treatment of experimental inflammatory bowel disease

MC Denis, D Roy, PR Yeganeh, Y Desjardins… - Clinical …, 2016 - portlandpress.com
Diets rich in fruits and vegetables may reduce oxidative stress (OxS) and inflammation via
several mechanisms. These beneficial effects may be due to their high polyphenol content …