User profiles for "author:Charlotte Hedin"

Charlotte Hedin

Karolinska Institutet
Verified email at ki.se
Cited by 3717

Evidence for the use of probiotics and prebiotics in inflammatory bowel disease: a review of clinical trials

C Hedin, K Whelan, JO Lindsay - Proceedings of the Nutrition Society, 2007 - cambridge.org
Human subjects and their enteric microbiota have evolved together to reach a state of
mutual tolerance. Mounting evidence from both animal models and human studies suggests …

Mechanisms of mucosal healing: treating inflammatory bowel disease without immunosuppression?

EJ Villablanca, K Selin, CRH Hedin - Nature Reviews Gastroenterology …, 2022 - nature.com
Almost all currently available treatments for inflammatory bowel disease (IBD) act by
inhibiting inflammation, often blocking specific inflammatory molecules. However, given the …

ECCO guidelines on therapeutics in ulcerative colitis: medical treatment

T Raine, S Bonovas, J Burisch… - Journal of Crohn's …, 2022 - academic.oup.com
Ulcerative colitis [UC] is a chronic inflammatory bowel disease [IBD] characterised by colonic
inflammation extending to a variable extent from the rectum. Care of the patient with UC …

Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease

JL Benjamin, CRH Hedin, A Koutsoumpas, SC Ng… - Gut, 2011 - gut.bmj.com
Introduction The commensal intestinal microbiota drive the inflammation associated with
Crohn's disease. However, bacteria such as bifidobacteria and Faecalibacterium prausnitzii …

[HTML][HTML] Scalable in situ single-cell profiling by electrophoretic capture of mRNA using EEL FISH

LE Borm, A Mossi Albiach, CCA Mannens… - Nature …, 2023 - nature.com
Methods to spatially profile the transcriptome are dominated by a trade-off between
resolution and throughput. Here we develop a method named Enhanced ELectric …

Increased intestinal permeability is associated with later development of Crohn's disease

W Turpin, SH Lee, JAR Garay, KL Madsen… - Gastroenterology, 2020 - Elsevier
Background & Aims Increased intestinal permeability has been associated with Crohn's
disease (CD), but it is not clear whether it is a cause or result of the disease. We performed a …

Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota

JL Benjamin, CRH Hedin… - Inflammatory bowel …, 2012 - academic.oup.com
Abstract Background Patients with Crohn's disease (CD) have an intestinal dysbiosis with
components of the microbiota exerting differential immune effects. Smoking is associated …

European Crohn's and colitis guidelines on sexuality, fertility, pregnancy, and lactation

J Torres, M Chaparro, M Julsgaard… - Journal of Crohn's …, 2023 - academic.oup.com
2. Methods This document represents the third version of the European Consensus on
reproduction in IBD. The development of this Consensus included the formulation of …

ECCO guidelines on therapeutics in ulcerative colitis: surgical treatment

A Spinelli, S Bonovas, J Burisch… - Journal of Crohn's …, 2022 - academic.oup.com
This is the second of a series of two articles reporting the European Crohn's and Colitis
Organisation [ECCO] evidence-based consensus on the management of adult patients with …

[HTML][HTML] Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing

L Mazzurana, P Czarnewski, V Jonsson, L Wigge… - Cell research, 2021 - nature.com
The impact of the microenvironment on innate lymphoid cell (ILC)-mediated immunity in
humans remains largely unknown. Here we used full-length Smart-seq2 single-cell RNA …