[HTML][HTML] Probiotics, prebiotics and amelioration of diseases

YL Tsai, TL Lin, CJ Chang, TR Wu, WF Lai… - Journal of biomedical …, 2019 - Springer
Dysbiosis of gut microbiota is closely related to occurrence of many important chronic
inflammations-related diseases. So far the traditionally prescribed prebiotics and probiotics …

Anti-obesogenic and antidiabetic effects of plants and mushrooms

J Martel, DM Ojcius, CJ Chang, CS Lin, CC Lu… - Nature Reviews …, 2017 - nature.com
Obesity is reaching global epidemic proportions as a result of factors such as high-calorie
diets and lack of physical exercise. Obesity is now considered to be a medical condition …

[HTML][HTML] Next generation probiotics in disease amelioration

CJ Chang, TL Lin, YL Tsai, TR Wu, WF Lai… - Journal of food and drug …, 2019 - Elsevier
Studies on the role of gut commensal bacteria in health development have rapidly attracted
much more attention beyond the classical pathogens over the last decade. Many important …

[HTML][HTML] Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota

CJ Chang, CS Lin, CC Lu, J Martel, YF Ko… - Nature …, 2015 - nature.com
Obesity is associated with low-grade chronic inflammation and intestinal dysbiosis.
Ganoderma lucidum is a medicinal mushroom used in traditional Chinese medicine with …

Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis

TR Wu, CS Lin, CJ Chang, TL Lin, J Martel, YF Ko… - Gut, 2019 - gut.bmj.com
Objective The medicinal fungus Ophiocordyceps sinensis and its anamorph Hirsutella
sinensis have a long history of use in traditional Chinese medicine for their …

Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory Parabacteroides goldsteinii lipopolysaccharide

HC Lai, TL Lin, TW Chen, YL Kuo, CJ Chang, TR Wu… - Gut, 2022 - gut.bmj.com
Objective Chronic obstructive pulmonary disease (COPD) is a global disease characterised
by chronic obstruction of lung airflow interfering with normal breathing. Although the …

Effects of obesity on depression: a role for inflammation and the gut microbiota

J Schachter, J Martel, CS Lin, CJ Chang, TR Wu… - Brain, Behavior, and …, 2018 - Elsevier
Depression is a mental disorder associated with environmental, genetic and psychological
factors. Recent studies indicate that chronic neuro-inflammation may affect brain physiology …

Role of gut microbiota in identification of novel TCM-derived active metabolites

TL Lin, CC Lu, WF Lai, TS Wu, JJ Lu, YM Chen… - Protein & …, 2021 - academic.oup.com
Abstract Traditional Chinese Medicine (TCM) has been extensively used to ameliorate
diseases in Asia for over thousands of years. However, owing to a lack of formal scientific …

NK cells kill mycobacteria directly by releasing perforin and granulysin

CC Lu, TS Wu, YJ Hsu, CJ Chang… - Journal of leukocyte …, 2014 - academic.oup.com
Although the mechanisms underlying the cytotoxic effect of NK cells on tumor cells and
intracellular bacteria have been studied extensively, it remains unclear how these cells kill …

[PDF][PDF] Impact of the gut microbiota, prebiotics, and probiotics on human health and disease

CS Lin, CJ Chang, CC Lu, J Martel… - Biomedical …, 2014 - advancedvitality.s3.amazonaws.com
More than 100 trillion (1014) microbes inhabit the human gastrointestinal (GI) tract, and the
total number of genes derived from these microbes exceeds that of the human genome by at …