Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant
tumours that can arise at any point of the biliary tree. Their incidence is increasing globally …

Background The risk of recurrence of gastrointestinal stromal tumour (GIST) after surgery
needs to be estimated when considering adjuvant systemic therapy. We assessed …

Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying
development, disease, and regeneration. As organoid research expands, the need for clear …

Patient-derived organoids (PDOs) have recently emerged as robust preclinical models;
however, their potential to predict clinical outcomes in patients has remained unclear. We …

Hepatocellular carcinoma (HCC) is characterized by a propensity for multifocality, growth by
local spread, and dysregulation of multiple signaling pathways. These features may be …

Although the inflammation‐associated cytokine interleukin‐6 (IL‐6) has been implicated in
cholangiocarcinoma growth, the relationship between IL‐6 and oncogenic changes is …

Inactivation of mismatch repair (MMR) is the cause of the common cancer predisposition
disorder Lynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer …

The overexpression of microRNA-21 (miR-21) is linked to a number of human tumors
including colorectal cancer, where it appears to regulate the expression of tumor suppressor …

Background & Aims Cholangiocarcinoma (CCA) is a rare and heterogeneous biliary cancer,
whose incidence and related mortality is increasing. This study investigates the clinical …

MicroRNA deregulation is frequent in human colorectal cancers (CRCs), but little is known
as to whether it represents a bystander event or actually drives tumor progression in vivo …