Liver cancer: connections with obesity, fatty liver, and cirrhosis

A Marengo, C Rosso, E Bugianesi - Annual review of medicine, 2016 - annualreviews.org
The burden of hepatocellular carcinoma (HCC), the most common form of liver cancer, is
steadily growing because obesity, type 2 diabetes, and nonalcoholic fatty liver disease …

[HTML][HTML] Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis

EA Selvaraj, FE Mózes, ANA Jayaswal… - Journal of …, 2021 - Elsevier
Background and Aims Vibration-controlled transient elastography (VCTE), point shear wave
elastography (pSWE), 2-dimensional shear wave elastography (2DSWE), magnetic …

[HTML][HTML] Non-alcoholic fatty liver disease and extra-hepatic cancers

C Sanna, C Rosso, M Marietti, E Bugianesi - International journal of …, 2016 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease but the
second cause of death among NAFLD patients are attributed to malignancies at both …

Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

O Govaere, S Cockell, D Tiniakos, R Queen… - Science translational …, 2020 - science.org
The mechanisms that drive nonalcoholic fatty liver disease (NAFLD) remain incompletely
understood. This large multicenter study characterized the transcriptional changes that occur …

[PDF][PDF] Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance

M Gaggini, F Carli, C Rosso, E Buzzigoli… - …, 2018 - Wiley Online Library
Plasma concentrations of amino acids (AAs), in particular, branched chain AAs (BCAAs), are
often found increased in nonalcoholic fatty liver disease (NAFLD); however, if this is due to …

Lean NAFLD: a distinct entity shaped by differential metabolic adaptation

F Chen, S Esmaili, GB Rogers, E Bugianesi, S Petta… - Hepatology, 2020 - journals.lww.com
Conclusions This study demonstrates that E. multilocularis can induce T‐cell exhaustion
through inhibitory receptor TIGIT, and that blocking this checkpoint may reverse the …

[HTML][HTML] MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals

B Donati, P Dongiovanni, S Romeo, M Meroni… - Scientific reports, 2017 - nature.com
Nonalcoholic fatty liver disease (NAFLD) represents an emerging cause of hepatocellular
carcinoma (HCC), especially in non-cirrhotic individuals. The rs641738 C> T …

Caucasian lean subjects with non-alcoholic fatty liver disease share long-term prognosis of non-lean: time for reappraisal of BMI-driven approach?

R Younes, O Govaere, S Petta, L Miele, D Tiniakos… - Gut, 2022 - gut.bmj.com
Objective The full phenotypic expression of non-alcoholic fatty liver disease (NAFLD) in lean
subjects is incompletely characterised. We aimed to investigate prevalence, characteristics …

Long-term outcomes and predictive ability of non-invasive scoring systems in patients with non-alcoholic fatty liver disease

R Younes, GP Caviglia, O Govaere, C Rosso… - Journal of …, 2021 - Elsevier
Background & Aims Non-invasive scoring systems (NSS) are used to identify patients with
non-alcoholic fatty liver disease (NAFLD) who are at risk of advanced fibrosis, but their …

[HTML][HTML] Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual …

FE Mózes, JA Lee, Y Vali, O Alzoubi… - The Lancet …, 2023 - thelancet.com
Background Histologically assessed liver fibrosis stage has prognostic significance in
patients with non-alcoholic fatty liver disease (NAFLD) and is accepted as a surrogate …