Emerging therapies for the treatment of hepatitis C

CM Lange, IM Jacobson, CM Rice… - EMBO molecular …, 2014 - embopress.org
Opportunities to treat infection with hepatitis C virus (HCV) are evolving rapidly. From the
introduction of interferon‐α monotherapy in 1992 to the approval of telaprevir‐and …

[HTML][HTML] IL28B single nucleotide polymorphisms in the treatment of hepatitis C

CM Lange, S Zeuzem - Journal of hepatology, 2011 - Elsevier
Recent genome-wide association studies (GWAS) have identified genetic variations near
the IL28B gene which are strongly associated with spontaneous and treatment-induced …

[HTML][HTML] Perspectives and challenges of interferon-free therapy for chronic hepatitis C

CM Lange, S Zeuzem - Journal of hepatology, 2013 - Elsevier
Recent data have clearly shown that a sustained virologic response can be achieved in
different HCV infected patient populations with various interferon-free treatment regimens …

[PDF][PDF] Severe lactic acidosis during treatment of chronic hepatitis B with entecavir in patients with impaired liver function

CM Lange, J Bojunga, WP Hofmann, K Wunder… - …, 2009 - Wiley Online Library
Entecavir is a potent nucleoside inhibitor of the hepatitis B virus (HBV) polymerase with a
high antiviral efficacy and a high genetic barrier to viral resistance. After approval in 2006 …

[PDF][PDF] Low vitamin D serum concentration is associated with high levels of hepatitis B virus replication in chronically infected patients

H Farnik, J Bojunga, A Berger, R Allwinn… - …, 2013 - Wiley Online Library
Vitamin D is an important immune modulator that plays an emerging role in inflammatory
and metabolic liver diseases, including infection with hepatitis C virus (HCV). In contrast, the …

Atezolizumab and bevacizumab in patients with advanced hepatocellular carcinoma with impaired liver function and prior systemic therapy: a real-world experience

T de Castro, LS Jochheim, M Bathon… - Therapeutic …, 2022 - journals.sagepub.com
Objective: Evaluation of the efficacy and safety of atezolizumab/bevacizumab in a real-world
HCC cohort, including patients with impaired liver function and prior systemic therapy …

Bacterial infection‐triggered acute‐on‐chronic liver failure is associated with increased mortality

MM Mücke, T Rumyantseva, VT Mücke… - Liver …, 2018 - Wiley Online Library
Abstract Background & Aims Acute‐on‐chronic liver failure (ACLF) is characterized by an
acute deterioration of liver function in patients with cirrhosis in combination with recently …

[HTML][HTML] Humoral response to SARS-CoV-2 vaccination in liver transplant recipients–a single-center experience

J Rashidi-Alavijeh, A Frey, M Passenberg, J Korth… - Vaccines, 2021 - mdpi.com
Vaccination against SARS-CoV-2 infection is currently approved and shows favorable
outcomes, but little known about antibody responses in solid organ transplant recipients …

[HTML][HTML] Treating hepatitis D with bulevirtide–Real-world experience from 114 patients

C Dietz-Fricke, F Tacke, C Zöllner, M Demir… - Jhep Reports, 2023 - Elsevier
Background & Aims Bulevirtide is a first-in-class entry inhibitor of hepatitis B surface antigen.
In July 2020, bulevirtide was conditionally approved for the treatment of hepatitis D, the most …

[HTML][HTML] Granulocyte-colony stimulating factor (G-CSF) to treat acute-on-chronic liver failure: a multicenter randomized trial (GRAFT study)

C Engelmann, A Herber, A Franke, T Bruns… - Journal of …, 2021 - Elsevier
Background & Aims Based on positive results from small single center studies, granulocyte-
colony stimulating factor (G-CSF) is being widely used for the treatment of patients with …