[HTML][HTML] Chemoresistance in pancreatic cancer
S Zeng, M Pöttler, B Lan, R Grützmann… - International journal of …, 2019 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC), generally known as pancreatic cancer (PC),
ranks the fourth leading cause of cancer-related deaths in the western world. While the …
ranks the fourth leading cause of cancer-related deaths in the western world. While the …
[HTML][HTML] Precursor lesions for sporadic pancreatic cancer: PanIN, IPMN, and MCN
M Distler, D Aust, J Weitz, C Pilarsky… - BioMed research …, 2014 - hindawi.com
Pancreatic cancer is still a dismal disease. The high mortality rate is mainly caused by the
lack of highly sensitive and specific diagnostic tools, and most of the patients are diagnosed …
lack of highly sensitive and specific diagnostic tools, and most of the patients are diagnosed …
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
KP Olive, MA Jacobetz, CJ Davidson, A Gopinathan… - Science, 2009 - science.org
Pancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers in part
because it is insensitive to many chemotherapeutic drugs. Studying a mouse model of PDA …
because it is insensitive to many chemotherapeutic drugs. Studying a mouse model of PDA …
Intraductal papillary mucinous tumors of the pancreas: biology, diagnosis, and treatment
R Grützmann, M Niedergethmann, C Pilarsky… - The …, 2010 - academic.oup.com
Pancreatic intraductal papillary mucinous neoplasms (IPMNs) rank among the most
common cystic tumors of the pancreas. For a long time they were misdiagnosed as …
common cystic tumors of the pancreas. For a long time they were misdiagnosed as …
Genomic analyses identify molecular subtypes of pancreatic cancer
Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32
recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH …
recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH …
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
SA Melo, LB Luecke, C Kahlert, AF Fernandez… - Nature, 2015 - nature.com
Exosomes are lipid-bilayer-enclosed extracellular vesicles that contain proteins and nucleic
acids. They are secreted by all cells and circulate in the blood. Specific detection and …
acids. They are secreted by all cells and circulate in the blood. Specific detection and …
The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer
AM Krebs, J Mitschke, M Lasierra Losada… - Nature cell …, 2017 - nature.com
Metastasis is the major cause of cancer-associated death. Partial activation of the epithelial-
to-mesenchymal transition program (partial EMT) was considered a major driver of tumour …
to-mesenchymal transition program (partial EMT) was considered a major driver of tumour …
DNA methylation biomarkers for blood-based colorectal cancer screening
C Lofton-Day, F Model, T DeVos, R Tetzner… - Clinical …, 2008 - academic.oup.com
Background: Sensitive, specific blood-based tests are difficult to develop unless steps are
taken to maximize performance characteristics at every stage of marker discovery and …
taken to maximize performance characteristics at every stage of marker discovery and …
Circulating Methylated SEPT9 DNA in Plasma Is a Biomarker for Colorectal Cancer
T Devos, R Tetzner, F Model, G Weiss… - Clinical …, 2009 - academic.oup.com
Background: The presence of aberrantly methylated SEPT9 DNA in plasma is highly
correlated with the occurrence of colorectal cancer. We report the development of a new …
correlated with the occurrence of colorectal cancer. We report the development of a new …
[PDF][PDF] Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling
S Weissmueller, E Manchado, M Saborowski, JP Morris… - Cell, 2014 - cell.com
Missense mutations in the p53 tumor suppressor inactivate its antiproliferative properties but
can also promote metastasis through a gain-of-function activity. We show that sustained …
can also promote metastasis through a gain-of-function activity. We show that sustained …