Human UDP-glucuronosyltransferases: metabolism, expression, and disease
RH Tukey, CP Strassburg - Annual review of pharmacology and …, 2000 - annualreviews.org
In vertebrates, the glucuronidation of small lipophilic agents is catalyzed by the endoplasmic
reticulum UDP-glucuronosyltransferases (UGTs). This metabolic pathway leads to the …
reticulum UDP-glucuronosyltransferases (UGTs). This metabolic pathway leads to the …
Portopulmonary hypertension and hepatopulmonary syndrome
MM Hoeper, MJ Krowka, CP Strassburg - The Lancet, 2004 - thelancet.com
The clinically and pathophysiologically distinct entities of portopulmonary hypertension and
hepatopulmonary syndrome occur in a substantial proportion of patients who have …
hepatopulmonary syndrome occur in a substantial proportion of patients who have …
[PDF][PDF] Assessment of biopsy‐proven liver fibrosis by two‐dimensional shear wave elastography: An individual patient data‐based meta‐analysis
E Herrmann, V de Lédinghen, C Cassinotto… - …, 2018 - Wiley Online Library
Two‐dimensional shear wave elastography (2D‐SWE) has proven to be efficient for the
evaluation of liver fibrosis in small to moderate‐sized clinical trials. We aimed at running a …
evaluation of liver fibrosis in small to moderate‐sized clinical trials. We aimed at running a …
Budesonide induces remission more effectively than prednisone in a controlled trial of patients with autoimmune hepatitis
MP Manns, M Woynarowski, W Kreisel, Y Lurie, C Rust… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Autoimmune hepatitis (AIH) is a chronic liver disease associated
with cirrhosis and liver failure. Corticosteroid therapy induces long-term remission but has …
with cirrhosis and liver failure. Corticosteroid therapy induces long-term remission but has …
Patient age, sex, and inflammatory bowel disease phenotype associate with course of primary sclerosing cholangitis
Background & Aims Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary
disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of …
disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of …
[PDF][PDF] Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19
Longitudinal analyses of the innate immune system, including the earliest time points, are
essential to understand the immunopathogenesis and clinical course of coronavirus disease …
essential to understand the immunopathogenesis and clinical course of coronavirus disease …
[HTML][HTML] Effect of sarcopenia on survival in patients with cirrhosis: a meta-analysis
X Tantai, Y Liu, YH Yeo, M Praktiknjo, E Mauro… - Journal of …, 2022 - Elsevier
Background & Aims The association between sarcopenia and prognosis in patients with
cirrhosis remains to be determined. In this study, we aimed to quantify the association …
cirrhosis remains to be determined. In this study, we aimed to quantify the association …
[HTML][HTML] Expression of the UDP-glucuronosyltransferase 1A locus in human colon: identification and characterization of the novel extrahepatic UGT1A8
CP Strassburg, MP Manns, RH Tukey - Journal of Biological Chemistry, 1998 - ASBMB
UDP-glucuronosyltransferases (UGT) catalyze the conjugation of lipophilic exobiotic and
endobiotic compounds, which leads to the excretion of hydrophilic glucuronides via bile or …
endobiotic compounds, which leads to the excretion of hydrophilic glucuronides via bile or …
Differential Expression of the UGT1A Locus in Human Liver, Biliary, and Gastric Tissue: Identification ofUGT1A7 and UGT1A10 Transcripts in Extrahepatic Tissue
CP Strassburg, K Oldhafer, MP Manns, RH Tukey - Molecular pharmacology, 1997 - ASPET
Family 1 UDP-glucuronosyltransferases (UGTs)(UGT1A) are encoded by a locus that
predicts the existence of at least nine individual proteins. The different proteins are …
predicts the existence of at least nine individual proteins. The different proteins are …
Chemokine (C‐C motif) receptor 2–positive monocytes aggravate the early phase of acetaminophen‐induced acute liver injury
JC Mossanen, O Krenkel, C Ergen, O Govaere… - Hepatology, 2016 - journals.lww.com
Acetaminophen (APAP, paracetamol) poisoning is a leading cause of acute liver failure
(ALF) in humans and induces hepatocyte necrosis, followed by activation of the innate …
(ALF) in humans and induces hepatocyte necrosis, followed by activation of the innate …