Little is known about how metabolites couple tissue-specific stem cell function with
physiology. Here we show that, in the mammalian small intestine, the expression of Hmgcs2 …

Sex exerts a profound impact on cancer incidence, spectrum and outcomes, yet the
molecular and genetic bases of such sex differences are ill-defined and presumptively …

Lung cancer is a devastating disease that remains a top cause of cancer mortality. Despite
improvements with targeted and immunotherapies, the majority of patients with lung cancer …

The extent and nature of epigenomic changes associated with melanoma progression is
poorly understood. Through systematic epigenomic profiling of 35 epigenetic modifications …

Germline telomere maintenance defects are associated with an increased incidence of
inflammatory diseases in humans, yet whether and how telomere dysfunction causes …

Reactivation of neurogenesis by endogenous Neural Stem/Progenitor Cells (NS/PC) in the
adult brain or spinal cord holds the key for treatment of CNS injuries as well as …

Summary β-hydroxybutyrate (β-OHB) is an essential metabolic energy source during fasting
and functions as a chromatin regulator by lysine β-hydroxybutyrylation (Kbhb) modification …

Genetic studies have placed the Fgfr1 gene at the top of major ontogenic pathways that
enable gastrulation, tissue development and organogenesis. Using genome-wide …

Histone methyltransferase KMT2D harbors frequent loss-of-function somatic point mutations
in several tumor types, including melanoma. Here, we identify KMT2D as a potent tumor …

The dynamic evolution of chromatin state patterns during metastasis, their relationship with
bona fide genetic drivers, and their therapeutic vulnerabilities are not completely …