[HTML][HTML] Iron metabolism in ferroptosis

X Chen, C Yu, R Kang, D Tang - Frontiers in cell and developmental …, 2020 - frontiersin.org
Ferroptosis is a form of regulated cell death that is characterized by iron-dependent
oxidative damage and subsequent plasma membrane ruptures and the release of damage …

Cellular degradation systems in ferroptosis

X Chen, C Yu, R Kang, G Kroemer… - Cell Death & Differentiation, 2021 - nature.com
In eukaryotic cells, macromolecular homeostasis requires selective degradation of damaged
units by the ubiquitin-proteasome system (UPS) and autophagy. Thus, dysfunctional …

The genetics of Henoch–Schönlein purpura: a systematic review and meta-analysis

X He, C Yu, P Zhao, Y Ding, X Liang, Y Zhao… - Rheumatology …, 2013 - Springer
Henoch–Schönlein purpura (HSP) is the most common form of systemic vasculitis of
unknown etiology. This study aimed at reviewing published studies investigating the …

Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury

RF Souza, X Huo, V Mittal, CM Schuler, SW Carmack… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: Reflux esophagitis is believed to be caused by the caustic effects of
refluxed gastric acid on esophageal epithelial cells. However, caustic chemical injuries …

Prevalence and associated factors of depression and anxiety among nurses during the outbreak of COVID-19 in China: A cross-sectional study

R Zheng, Y Zhou, Y Fu, Q Xiang, F Cheng… - International journal of …, 2021 - Elsevier
Abstract Background Coronavirus disease 2019 (COVID-19) is a public health emergency of
international concern and has caused traumatic experience for nurses worldwide. However …

Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilic oesophagitis and GORD

E Cheng, X Zhang, X Huo, C Yu, Q Zhang, DH Wang… - Gut, 2013 - gut.bmj.com
Objective Eosinophilic oesophagitis (EoE) and gastro-oesophageal reflux disease (GORD)
can have similar clinical and histological features. Proton pump inhibitors (PPIs) are used to …

[HTML][HTML] A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis

X Chen, J Huang, C Yu, J Liu, W Gao, J Li… - Nature …, 2022 - nature.com
Ferroptosis is a type of lipid peroxidation-dependent cell death that is emerging as a
therapeutic target for cancer. However, the mechanisms of ferroptosis during the generation …

[HTML][HTML] Omeprazole blocks STAT6 binding to the eotaxin-3 promoter in eosinophilic esophagitis cells

X Zhang, E Cheng, X Huo, C Yu, Q Zhang, TH Pham… - PloS one, 2012 - journals.plos.org
Background Patients who have esophageal eosinophilia without gastroesophageal reflux
disease (GERD) nevertheless can respond to proton pump inhibitors (PPIs), which can have …

Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer

J Li, J Liu, Z Zhou, R Wu, X Chen, C Yu… - Science translational …, 2023 - science.org
Lipid peroxidation–dependent ferroptosis has become an emerging strategy for tumor
therapy. However, current strategies not only selectively induce ferroptosis in malignant cells …

Deoxycholic acid causes DNA damage while inducing apoptotic resistance through NF-κB activation in benign Barrett's epithelial cells

X Huo, S Juergens, X Zhang… - American Journal …, 2011 - journals.physiology.org
Gastroesophageal reflux is associated with adenocarcinoma in Barrett's esophagus, but the
incidence of this tumor is rising, despite widespread use of acid-suppressing medications …