In recent years, our understanding of genetic predisposition to breast cancer has advanced
significantly. Three classes of predisposition factors, categorized by their associated risks of …

Abstract The European Collaborative on Personalized Early Detection and Prevention of
Breast Cancer (ENVISION) brings together several international research consortia working …

BRCA1 and BRCA2 gene pathogenic variants account for most hereditary breast cancer
and are increasingly used to determine eligibility for PARP inhibitor (PARPi) therapy of …

A complete understanding of how exposure to environmental substances promotes cancer
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two …

Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …

Background Germline loss-of-function mutations in PALB2 are known to confer a
predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred …

Breast cancer is the most common cancer in women in developed countries. To identify
common breast cancer susceptibility alleles, we conducted a genome-wide association …

Background During the COVID-19 lockdown, referrals via the 2-week-wait urgent pathway
for suspected cancer in England, UK, are reported to have decreased by up to 84%. We …

Genome-wide association studies (GWAS) and large-scale replication studies have
identified common variants in 79 loci associated with breast cancer, explaining∼ 14% of the …

Recently, RAD51C mutations were identified in families with breast and ovarian cancer. This
observation prompted us to investigate the role of RAD51D in cancer susceptibility. We …