Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

B Routy, E Le Chatelier, L Derosa, CPM Duong… - Science, 2018 - science.org
Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis induce sustained clinical
responses in a sizable minority of cancer patients. We found that primary resistance to ICIs …

Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer

L Derosa, B Routy, AM Thomas, V Iebba, G Zalcman… - Nature medicine, 2022 - nature.com
Aside from PD-L1 expression, biomarkers of response to immune checkpoint inhibitors (ICIs)
in non-small-cell lung cancer (NSCLC) are needed. In a previous retrospective analysis, we …

Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

B Routy, JG Lenehan, WH Miller Jr, R Jamal… - Nature medicine, 2023 - nature.com
Fecal microbiota transplantation (FMT) represents a potential strategy to overcome
resistance to immune checkpoint inhibitors in patients with refractory melanoma; however …

The gut microbiome associates with immune checkpoint inhibition outcomes in patients with advanced non–small cell lung cancer

T Hakozaki, C Richard, A Elkrief, Y Hosomi… - Cancer Immunology …, 2020 - AACR
The gut microbiome (GM) plays an important role in shaping systemic immune responses
and influences immune checkpoint inhibitor (ICI) efficacy. Antibiotics worsen clinical …

A microbiota-modulated checkpoint directs immunosuppressive intestinal T cells into cancers

M Fidelle, C Rauber, C Alves Costa Silva, AL Tian… - Science, 2023 - science.org
Antibiotics (ABX) compromise the efficacy of programmed cell death protein 1 (PD-1)
blockade in cancer patients, but the mechanisms underlying their immunosuppressive …

Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage

A Fluckiger, R Daillère, M Sassi, BS Sixt, P Liu, F Loos… - Science, 2020 - science.org
Intestinal microbiota have been proposed to induce commensal-specific memory T cells that
cross-react with tumor-associated antigens. We identified major histocompatibility complex …

A natural polyphenol exerts antitumor activity and circumvents anti–PD-1 resistance through effects on the gut microbiota

M Messaoudene, R Pidgeon, C Richard, M Ponce… - Cancer Discovery, 2022 - AACR
Several approaches to manipulate the gut microbiome for improving the activity of cancer
immune-checkpoint inhibitors (ICI) are currently under evaluation. Here, we show that oral …

Helicobacter pylori infection has a detrimental impact on the efficacy of cancer immunotherapies

P Oster, L Vaillant, E Riva, B McMillan, C Begka… - Gut, 2022 - gut.bmj.com
Objective In this study, we determined whether Helicobacter pylori (H. pylori) infection
dampens the efficacy of cancer immunotherapies. Design Using mouse models, we …

Antibiotics are associated with decreased progression-free survival of advanced melanoma patients treated with immune checkpoint inhibitors

A Elkrief, L El Raichani, C Richard… - …, 2019 - Taylor & Francis
Background: The gut microbiota has been shown to be an important determinant of the
efficacy of immune checkpoint inhibitions (ICI) in cancer. Several lines of evidence suggest …

[HTML][HTML] Optimized fractionated radiotherapy with anti-PD-L1 and anti-TIGIT: a promising new combination

M Grapin, C Richard, E Limagne, R Boidot… - … for immunotherapy of …, 2019 - Springer
Purpose/objective Radiotherapy (RT) induces an immunogenic antitumor response, but also
some immunosuppressive barriers. It remains unclear how different fractionation protocols …