Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice
Hepatitis C virus (HCV) has no animal reservoir, infecting only humans. To investigate
species barrier determinants limiting infection of rodents, murine liver complementary DNA …
species barrier determinants limiting infection of rodents, murine liver complementary DNA …
[PDF][PDF] Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver‐derived cells
A Frentzen, Anggakusuma, E Guerlevik… - …, 2014 - Wiley Online Library
Only humans and chimpanzees are susceptible to chronic infection by hepatitis C virus
(HCV). The restricted species tropism of HCV is determined by distinct host factor …
(HCV). The restricted species tropism of HCV is determined by distinct host factor …
Hepatitis C reference viruses highlight potent antibody responses and diverse viral functional interactions with neutralising antibodies
D Bankwitz, A Bahai, M Labuhn, M Doepke, C Ginkel… - Gut, 2021 - gut.bmj.com
Objective Neutralising antibodies are key effectors of infection-induced and vaccine-induced
immunity. Quantification of antibodies' breadth and potency is critical for understanding the …
immunity. Quantification of antibodies' breadth and potency is critical for understanding the …
Initial hepatitis C virus infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro-and antiviral elements
Transcriptional profiling provides global snapshots of virus-mediated cellular
reprogramming, which can simultaneously encompass pro-and antiviral components. To …
reprogramming, which can simultaneously encompass pro-and antiviral components. To …
Characterization of hepatitis C virus intra-and intergenotypic chimeras reveals a role of the glycoproteins in virus envelopment
E Steinmann, J Doerrbecker, M Friesland… - Journal of …, 2013 - Am Soc Microbiol
Hepatitis C virus (HCV) is highly variable and associated with chronic liver disease. Viral
isolates are grouped into seven genotypes (GTs). Accumulating evidence indicates that viral …
isolates are grouped into seven genotypes (GTs). Accumulating evidence indicates that viral …
[HTML][HTML] Single-nucleotide variants in human CD81 influence hepatitis C virus infection of hepatoma cells
MP Alberione, R Moeller, J Kirui, C Ginkel… - Medical microbiology …, 2020 - Springer
An estimated number of 71 million people are living with chronic hepatitis C virus (HCV)
infection worldwide and 400,000 annual deaths are related to the infection. HCV entry into …
infection worldwide and 400,000 annual deaths are related to the infection. HCV entry into …
[PDF][PDF] Incorporation of primary patient‐derived glycoproteins into authentic infectious hepatitis C virus particles
J Doerrbecker, M Friesland, N Riebesehl, C Ginkel… - …, 2014 - Wiley Online Library
The Japanese fulminant hepatitis‐1 (JFH1)‐based hepatitis C virus (HCV) infection system
has permitted analysis of the complete viral replication cycle in vitro. However, lack of robust …
has permitted analysis of the complete viral replication cycle in vitro. However, lack of robust …
Analysis of serine codon conservation reveals diverse phenotypic constraints on hepatitis C virus glycoprotein evolution
Serine is encoded by two divergent codon types, UCN and AGY, which are not
interchangeable by a single nucleotide substitution. Switching between codon types …
interchangeable by a single nucleotide substitution. Switching between codon types …