Due to difficulties in cell culture propagation, the mechanisms of hepatitis C virus (HCV)
entry are poorly understood. Here, postbinding cellular mechanisms of HCV entry were …

Host and viral proteinases are believed to be required for the production of at least nine
hepatitis C virus (HCV)-specific polyprotein cleavage products. Although several cleavages …

The hepatitis C virus (HCV) glycoproteins (E1 and E2) interact to form a heterodimeric
complex, which has been proposed as a functional subunit of the HCV virion envelope. As …

Hepatitis C virus (HCV) encodes two viral envelope glycoproteins. E1 contains 4 or 5 N-
linked glycosylation sites and E2 contains up to 11, with most of the sites being well …

Although biological and biochemical data have been accumulated on most hepatitis C virus
proteins, the structure and function of the 63-amino-acid p7 polypeptide of this virus have …

Abstract Here, we identify (−)‐epigallocatechin‐3‐gallate (EGCG) as a new inhibitor of
hepatitis C virus (HCV) entry. EGCG is a flavonoid present in green tea extract belonging to …

The hepatitis C virus (HCV) genome encodes two envelope glycoproteins (E1 and E2).
These glycoproteins interact to form a noncovalent heterodimeric complex which is retained …

Hepatitis C virus (HCV) envelope glycoproteins are highly glycosylated, with generally 4 and
11 N-linked glycans on E1 and E2, respectively. Studies using mutated recombinant HCV …

BACKGROUND & AIMS: Silymarin is a mixture of flavonolignans extracted from the milk
thistle. Silymarin contains several molecules, including silibinin A, silibinin B, isosilibinin A …

For most membrane proteins, the transmembrane domain (TMD) is more than just an anchor
to the membrane. The TMDs of hepatitis C virus (HCV) envelope proteins E1 and E2 are …