Fibrosis is a common endpoint of clinical trials in chronic hepatitis C, and liver biopsy
remains the gold standard for fibrosis evaluation. However, variability in the distribution of …

There is growing evidence that senescent cells accumulate in vivo and are associated with
the aging process in parallel with the progressive erosion of telomeres. Because recent data …

Background & Aims:“Telangiectatic focal nodular hyperplasia” designate atypical lesions
considered as variants of focal nodular hyperplasia (FNH). However, because “telangiectatic …

Skin photoaging due to UV irradiation is a degenerative process that appears more and
more as a growing concern. Lipids, including oxysterols, are involved in degenerative …

Abstract A series of new 1, 2, 3-triazole linked coumarinopyrazole conjugates 4a-e and 5a-e
have been synthesized via the Copper (I)-catalysed Alkyne-Azide Cycloaddition (CuAAC) …

Background & Aims: Although the pathogenesis of focal nodular hyperplasia (FNH) of the
liver remains unclear, a vascular mechanism has been suspected. To gain insight into the …

In cirrhosis, lipopolysaccharide (LPS, a product of Gram-negative bacteria) in the blood may
cause septic shock. LPS-elicited induction of arterial inducible nitric oxide synthase (iNOS) …

The senile plaque is a hallmark lesion of Alzheimer disease (AD). We compared, without a
priori, the lipidome of the senile plaques and of the adjacent plaque-free neuropil. The …

Age-related macular degeneration (AMD) is the most common cause of severe vision loss
worldwide. Amyloid β involvement in degenerative diseases such as AMD is well known and …

BACKGROUND/AIMS: Endoplasmic reticulum (ER)-related unfolded protein response
(UPR) is mediated by PKR-like ER kinase (PERK), ATF6 and IRE1. PERK phosphorylates …