After the unexpected emergence of Bluetongue virus serotype 8 (BTV-8) in northern Europe
in 2006, another arbovirus, Schmallenberg virus (SBV), emerged in Europe in 2011 causing …

Influenza A virus (IAV) triggers a contagious acute respiratory disease that causes
considerable mortality annually. Recently, we established a role for the pattern-recognition …

Intracellular RNA virus infection is detected by the cytoplasmic RNA helicase RIG-I that plays
an essential role in signaling to the host antiviral response. Recently, the adapter molecule …

Abstract During 2000–2013, 4 genotypes of bluetongue virus (BTV) were detected in
Corsica, France. At the end of 2013, a compulsory BTV-1 vaccination campaign was initiated …

During the compulsory vaccination programme against bluetongue virus serotype 1 (BTV-1)
in Corsica (France) in 2014, a BTV strain belonging to a previously uncharacterized …

Bluetongue (BT) is a non-contagious animal disease transmitted by midges of the
Culicoides genus. The etiological agent is the BT virus (BTV) that induces a variety of clinical …

Rotavirus nonstructural protein NSP3 interacts specifically with the 3′ end of viral mRNAs,
with the eukaryotic translation initiation factor eIF4G, and with RoXaN, a cellular protein of …

The innate immune response is the first line of defence against viruses, involving the
production of type I IFN (IFN-α/β) and other pro-inflammatory cytokines that control the …

Background After viral infection and the stimulation of some pattern-recognition receptors,
TANK-binding kinase I (TBK1) is activated by K63-linked polyubiquitination followed by trans …

The mitochondria-bound adapter MAVS participates in IFN induction by recruitment of
downstream partners such as members of the TRAF family, leading to activation of NF-κB …