The gastrointestinal microbiome plays a pivotal role in physiological homeostasis of the
intestine as well as in the pathophysiology of diseases including inflammatory bowel …

Objective Although perturbations in mitochondrial function and structure have been
described in the intestinal epithelium of Crohn's disease and ulcerative colitis patients, the …

Paneth cell defects in Crohn's disease (CD) patients (called the Type I phenotype) are
associated with worse clinical outcomes. Recent studies have implicated mitochondrial …

Colorectal cancer exhibits aberrant activation of Wnt/β-catenin signaling. Many inhibitors of
the Wnt/β-catenin pathway have been tested for Wnt-dependent cancers including colorectal …

The Wnt/β-catenin signaling pathway is aberrantly activated in the majority of colorectal
cancer cases due to somatic mutations in the adenomatous polyposis coli (APC) gene …

Introduction Flavaglines are natural plant products shown to have anti‐inflammatory and anti‐
cancer effects. FL3 is a synthetic derivative of the flavagline Silvestrol, lacking its structural …

While the existence of cannabinoid 2 receptors (CB2R) in healthy brain is still uncertain, its
expression is associated with a variety of inflammatory processes. Activation of CB2R in …