Crohn's disease (CD) is a chronic progressive destructive disease. Currently available
instruments measure disease activity at a specific point in time. An instrument to measure …

Glucocorticoids (GC) are the most common used anti-inflammatory and immunosuppressive
drugs in the treatment of rheumatic and other inflammatory diseases. Their therapeutic …

Glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressant agents.
Unfortunately, they also produce serious side effects that limit their usage. This discrepancy …

Objective The aim of this study was to assess the efficacy and safety of adalimumab (ADA), a
recombinant human monoclonal antibody against tumour necrosis factor α (TNF), for the …

Background and aim Mesenchymal stromal cells (MSCs) are pluripotent cells that have
immunosuppressive effects both in vitro and in experimental colitis. Promising results of …

Background & Aims: The use of living, genetically modified bacteria is an effective approach
for topical delivery of immunomodulatory proteins. This strategy circumvents systemic side …

How the development of antibacterial T helper 17 (Th17) cells is selectively promoted by
antigen-presenting dendritic cells (DCs) is unclear. We showed that bacteria, but not viruses …

Mesenchymal stromal cells (MSCs) are currently under investigation for the treatment of
inflammatory disorders, including Crohn's disease. MSCs are pluripotent cells with …

Background & Aims Patients with perianal fistulizing Crohn's disease have a poor prognosis
because these lesions do not heal well. We evaluated the effects of local administration of …

Angiogenesis is crucial for the progression of colorectal carcinomas in which the
bioavailability of Vascular Endothelial Growth Factor (VEGF) plays a major role. VEGF …