Background Evidence suggests that cluster randomized trials are often poorly designed and
analysed. There is little recent research on the methodologic quality of cluster randomized …

This review examines the state of Bayesian thinking as Statistics in Medicine was launched
in 1982, reflecting particularly on its applicability and uses in medical research. It then looks …

Objectives To assess aspects of the internal validity of recently published cluster
randomised trials and explore the reporting of information useful in assessing the external …

Objective The colonic microbiota ferment dietary fibres, producing short chain fatty acids.
Recent evidence suggests that the short chain fatty acid propionate may play an important …

Context Plasma levels of C-reactive protein (CRP) are independently associated with risk of
coronary heart disease, but whether CRP is causally associated with coronary heart disease …

Background Lung delivery of plasmid DNA encoding the CFTR gene complexed with a
cationic liposome is a potential treatment option for patients with cystic fibrosis. We aimed to …

purpose. To quantify the variation in primary open-angle glaucoma (OAG) prevalence with
age, gender, race, year of publication, and survey methodology. methods. Medline …

Importance Norepinephrine is currently recommended as the first-line vasopressor in septic
shock; however, early vasopressin use has been proposed as an alternative. Objective To …

Background Cluster randomized trials are increasingly popular. In many of these trials,
cluster sizes are unequal. This can affect trial power, but standard sample size formulae for …

Objective To investigate whether selective serotonin reuptake inhibitor (SSRI)
antidepressants are associated with an increased risk of suicide related outcomes in adults …