Microsatellite instability (MSI) characterizes colorectal carcinomas (CRCs) in hereditary
nonpolyposis colorectal cancer (HNPCC) syndrome and a proportion of sporadic CRCs …

The evolution of glucagon has seen the transition from an impurity in the preparation of
insulin to the development of glucagon receptor agonists for use in type 1 diabetes. In type 2 …

Abstract Glucagonlike peptide 1 (GLP-1) receptor agonists have been efficacious for the
treatment of type 2 diabetes due to their ability to reduce weight and attenuate …

The high-affinity folate-binding protein (FBP) is primarily involved in the uptake of the 5-
methyltetrahydrofolate, and its expression may be physiologically regulated by the …

Glucagon is historically described as the counterregulatory hormone to insulin, induced by
fasting/hypoglycemia to raise blood glucose through action mediated in the liver. However, it …

Activation of oxytocin receptors has shown benefits in animal models of obstructive sleep
apnea (OSA). We tested if nocturnal oxytocin administration could have beneficial effects in …

BACKGROUND Hereditary non-polyposis colorectal cancer (HNPCC) is one of the most
common inherited disorders predisposing to cancer. The genes responsible for the disease …

Tirzepatide (LY3298176) is a dual GIP and GLP-1 receptor agonist under development for
the treatment of type 2 diabetes mellitus (T2DM), obesity, and nonalcoholic steatohepatitis …

Paracrine interactions between pancreatic islet cells have been proposed as a mechanism
to regulate hormone secretion and glucose homeostasis. Here, we demonstrate the …

The phenomenon of alternative splicing in the DNA mismatch repair genes MLH1 and
MSH2 was extensively investigated by coupled reverse transcription-polymerase chain …