Mucosal immunity is an important arm of the immune system because it operates in tissues
involved in everyday infectious defence as well as in tolerance against innocuous …

In cancer, infection and inflammation, the immune system's function can be dysregulated.
Instead of fighting disease, immune cells may increase pathology and suppress host …

The number of studies investigating the human gastrointestinal tract using various single-
cell profiling methods has increased substantially in the past few years. Although this …

Cerebrospinal fluid (CSF) from healthy individuals contains between 1,000 and 3,000
leukocytes per ml. Little is known about trafficking patterns of leukocytes between the …

Lymphocyte homing to secondary lymphoid tissue and lesions of chronic inflammation is
directed by multi-step interactions between the circulating cells and the specialized …

Lymphocyte homing to secondary lymphoid tissue is defined by a multistep sequence of
interactions between lymphocytes and endothelial cells in high endothelial venules (HEVs) …

The homeostatic chemokine CXCL13 (also called B cell-attracting chemokine 1 [BCA-1] or B-
lymphocyte chemoattractant [BLC]) is constitutively expressed in secondary lymphoid tissue …

Plasma cells (PCs) produce antibodies that mediate immunity after infection or vaccination.
In contrast to PCs in the bone marrow, PCs in the gut have been considered short lived. In …

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in the
world. Immunological analysis of the tumor microenvironment (immunoscore) shows great …

Naive T cells are usually excluded from nonlymphoid tissues. Only when such tertiary
tissues are subjected to chronic inflammation, such as in some (but not all) autoimmune …