Oxygen is a molecule that is central to cellular respiration and viability, yet there are multiple
physiologic and pathological contexts in which cells experience conditions of insufficient …

Migration and positioning of immune cells is fundamental for their differentiation and
recruitment at sites of infection. Besides the fundamental role played by chemokines and …

Recent studies have demonstrated dramatic shifts in metabolic supply-and-demand ratios
during inflammation, a process resulting in localized tissue hypoxia within inflammatory …

Acute intestinal inflammation involves early accumulation of neutrophils (PMNs) followed by
either resolution or progression to chronic inflammation. Based on recent evidence that …

IL-37, a newly described member of the IL-1 family, functions as a fundamental inhibitor of
innate inflammation and immunity. In the present study, we examined a role for IL-37 during …

MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but how
miRNA circuits orchestrate aberrant intestinal inflammation during inflammatory bowel …

Objective Eosinophils reside in the colonic mucosa and increase significantly during
disease. Although a number of studies have suggested that eosinophils contribute to the …

Organized lymphoid tissues like the thymus first appeared in jawed vertebrates around 500
million years ago and have evolved to equip the host with a network of specialized sites …

A complex biologic network regulates kidney perfusion under physiologic conditions. This
system is profoundly perturbed following renal ischemia, a leading cause of acute kidney …

Epithelial barrier dysfunction is a significant factor in many allergic diseases, including
eosinophilic esophagitis (EoE). Infiltrating leukocytes and tissue adaptations increase …