β blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomised, double-blind, placebo …
C Villanueva, A Albillos, J Genescà, JC Garcia-Pagan… - The lancet, 2019 - thelancet.com
Background Clinical decompensation of cirrhosis is associated with poor prognosis.
Clinically significant portal hypertension (CSPH), defined by a hepatic venous pressure …
Clinically significant portal hypertension (CSPH), defined by a hepatic venous pressure …
Addition of simvastatin to standard therapy for the prevention of variceal rebleeding does not reduce rebleeding but increases survival in patients with cirrhosis
JG Abraldes, C Villanueva, C Aracil, J Turnes… - Gastroenterology, 2016 - Elsevier
Background & Aims The combination of β-blockers and band ligation is the standard
approach to prevent variceal rebleeding, but bleeding recurs and mortality is high. The lipid …
approach to prevent variceal rebleeding, but bleeding recurs and mortality is high. The lipid …
[HTML][HTML] Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS
Background & Aims The relationship between acute-on-chronic liver failure (ACLF) and
acute variceal bleeding (AVB) is poorly understood. Specifically, the prevalence and …
acute variceal bleeding (AVB) is poorly understood. Specifically, the prevalence and …
[PDF][PDF] Preemptive‐TIPS improves outcome in high‐risk variceal bleeding: an observational study
V Hernández‐Gea, B Procopet, Á Giráldez… - …, 2019 - Wiley Online Library
Patients admitted with acute variceal bleeding (AVB) and Child‐Pugh C score (CP‐C) or
Child‐Pugh B plus active bleeding at endoscopy (CP‐B+ AB) are at high risk for treatment …
Child‐Pugh B plus active bleeding at endoscopy (CP‐B+ AB) are at high risk for treatment …
Carvedilol reduces the risk of decompensation and mortality in patients with compensated cirrhosis in a competing-risk meta-analysis
C Villanueva, F Torres, SK Sarin, HA Shah… - Journal of …, 2022 - Elsevier
Background & Aims Whether non-selective β-blockers can prevent decompensation of
cirrhosis warrants clarification. Carvedilol might be particularly effective since its intrinsic …
cirrhosis warrants clarification. Carvedilol might be particularly effective since its intrinsic …
Effects of early placement of transjugular portosystemic shunts in patients with high-risk acute variceal bleeding: a meta-analysis of individual patient data
O Nicoară-Farcău, G Han, M Rudler, D Angrisani… - Gastroenterology, 2021 - Elsevier
Background & Aims Compared with drugs plus endoscopy, placement of transjugular
portosystemic shunt within 72 hours of admission to the hospital (early or preventive …
portosystemic shunt within 72 hours of admission to the hospital (early or preventive …
Decompensation in advanced nonalcoholic fatty liver disease may occur at lower hepatic venous pressure gradient levels than in patients with viral disease
O Bassegoda, P Olivas, L Turco, M Mandorfer… - Clinical …, 2022 - Elsevier
Background & Aims Portal hypertension is the strongest predictor of hepatic
decompensation and death in patients with cirrhosis. However, its discriminatory accuracy in …
decompensation and death in patients with cirrhosis. However, its discriminatory accuracy in …
Bacterial infections adversely influence the risk of decompensation and survival in compensated cirrhosis
C Villanueva, A Albillos, J Genescà… - Journal of …, 2021 - Elsevier
Background & Aims The prognosis of compensated cirrhosis is good until decompensation.
In decompensated cirrhosis, bacterial infections (BIs) are common and increase the risk of …
In decompensated cirrhosis, bacterial infections (BIs) are common and increase the risk of …
[PDF][PDF] A randomized trial to assess whether portal pressure guided therapy to prevent variceal rebleeding improves survival in cirrhosis
C Villanueva, I Graupera, C Aracil, E Alvarado… - …, 2017 - Wiley Online Library
Monitoring the hemodynamic response of portal pressure (PP) to drug therapy accurately
stratifies the risk of variceal rebleeding (VRB). We assessed whether guiding therapy with …
stratifies the risk of variceal rebleeding (VRB). We assessed whether guiding therapy with …
Lowering portal pressure improves outcomes of patients with cirrhosis, with or without ascites: a meta-analysis
L Turco, C Villanueva, V La Mura… - Clinical …, 2020 - Elsevier
Background & Aims In unselected patients with cirrhosis, those with reductions in hepatic
venous pressure gradient (HVPG) to below a defined threshold (responders) have a …
venous pressure gradient (HVPG) to below a defined threshold (responders) have a …