Despite development of novel agents targeting oncogenic pathways, matching targeted
therapies to the genetic status of individual tumors is proving to be a daunting task for …

The reductions in mortality and morbidity being achieved among cancer patients with current
therapies represent a major achievement. However, given their mechanisms of action, many …

The increasing prevalence of heart failure poses enormous challenges for health care
systems worldwide. Despite effective medical interventions that target neurohumoral …

Phosphoinositide 3-kinase (PI3K) activity is crucial for leukocyte function, but the roles of the
four receptor-activated isoforms are unclear. Mice lacking heterotrimeric guanine nucleotide …

Abstract Phosphoinositide 3-kinases (PI3K) have long been considered promising drug
targets for the treatment of inflammatory and autoimmune disorders as well as cancer and …

Pentraxins are a superfamily of conserved proteins that are characterized by a cyclic
multimeric structure. The classical short pentraxins, C-reactive protein (CRP) and serum …

Abstract The PTEN/PI3K signaling pathway regulates a vast array of fundamental cellular
responses. We show that cardiomyocyte-specific inactivation of tumor suppressor PTEN …

The G protein-coupled, receptor-activated phosphoinositide 3-kinase γ (PI3Kγ) mediates
inflammatory responses and negatively controls cardiac contractility by reducing cAMP …

PTX3 is a prototypic long pentraxin that plays a non-redundant role in innate immunity
against selected pathogens and in female fertility. Here, we report that the infertility of Ptx3 …

Phosphoinositides serve crucial roles in cell physiology, ranging from cell signalling to
membrane traffic,. Among the seven eukaryotic phosphoinositides the best studied species …