BACKGROUND & AIMS: Tremelimumab is a monoclonal antibody that blocks cytotoxic T-
lymphocyte-associated antigen 4 (CTLA-4), an inhibitory co-receptor that interferes with T …

Tumor necrosis factor α (TNF-α) is a cytokine with pleiotropic properties that is induced in a
variety of pathological situations including viral infections. In this work, we analyzed the …

Protein N-terminal acetylation (Nt-acetylation) is an important mediator of protein function,
stability, sorting, and localization. Although the responsible enzymes are thought to be fairly …

ABSTRACT Indoleamine 2, 3-dioxygenase (IDO) is induced by proinflammatory cytokines
and by CTLA-4-expressing T cells and constitutes an important mediator of peripheral …

Background/Aims: Oxidative stress could play a role in the pathogenesis of hepatitis C virus
infection. We investigated the oxidant/antioxidant status in peripheral blood mononuclear …

It has been reported that hepatitis C virus (HCV) may cause oxidative stress in infected cells.
Patients with chronic hepatitis C exhibit an increased production of tumor necrosis factor-α …

IFN‐α/β link innate and adaptive immune responses by directly acting on naïve CD8+ T
cells. This concept unveiled in mice remains unexplored in humans. To investigate that …

BACKGROUND & AIMS: The mechanisms by which Foxp3+ T regulatory cells (Treg)
accumulate in HCV infected livers are not known. Here, we studied the role of chemokines …

Patients affected by cutaneous leishmaniasis need a topical treatment which cures lesions
without leaving scars. Lesions are produced not only by the parasite but also by an …

Migration of DC into lymphatic vessels ferries antigenic cargo and pro‐inflammatory stimuli
into the draining LN. Given that tissues under the influence of viral infections produce type I …